Figure 5
From: In silico investigation of ADAM12 effect on TGF-β receptors trafficking
High CIR like values correspond to sustained TGF- β signal. The 3 panels represent TGF-β activity overtime. TGF-β stimulation starts at 100 minutes. Panel A displays the nominal V-model behavior (CIRlike multiplier: 1). Panel B and C display ADAM12 models TGF-β activity, with V-model architecture. In panel B, the 5 CIRlike multiplier is almost the minimal value that satisfies the constraints; the signal is notably more sustained than in Panel A. Panel C exemplifies a model with an higher CIRlike multiplier (30); the signal is even more sustained.