Table 2 Physiological values of kinetic coefficients in V-model and Z-model

p _R - Receptors production rate

4

4

[9]

k _ie - Internalization rate towards endosome

0.1667

0.1667

[5, 12]

k _re - Recycling rate from endosome

0.0333

0.0333

[12, 13]

k _ic - Internalization rate towards caveosome

0.1667

0.1667

[5, 12]

k _rc - Recycling rate from caveosome

0.0333

0.0333

[12, 13]

k _cd - Constitutive degradation rate

0.0278

0.0056

[5]

k _lid - Ligand induced degradation rate

0.05

0.05

[5]

k _a - LRC formation rate

1

1

[9]