No evidence of BRCA2 mutations in chromosome 13q-linked Utah high-risk prostate cancer pedigrees

BMC Research Notes

Table 1 Characteristics of five high-risk prostate cancer pedigrees showing linkage evidence to chromosome 13q, BRCA2 region¹

Pedigree Identifier²	Max TLOD score on chr 13q	Location of max TLOD on chr 13	# prostate cancer cases in pedigree (genotyped)	# prostate cancer cases carrying segregating 13q haplotype³	Age at prostate cancer diagnosis (yrs)
9775803	1.423	23.0 cM	9(6)	7	57, 59, 61, 61, 64, 73, 74, 84, 87
9445402	1.191	23.0 cM	5(3)	5	60, 60, 78, 79, 82
9990205	1.050	36.0 cM	10(5)	3	59, 61, 62, 65, 66, 66, 70, 73, 77, 78
9434307	0.976	29.0 cM	12(6)	6, 7⁴	52, 59, 59, 63, 63, 69, 72, 74, 75, 76, 80, 85
9435901	0.953	23.0 cM	6(1)	4	54, 57, 62, 64, 67, 82

¹Pedigrees defined in Table 1 are based on the pedigree structure used for the linkage analysis.
²Pedigree identifier modified to protect confidentiality of pedigree members.
³Haplotype carrier status may be inferred based on descendant information rather than directly genotyped.
⁴Two distinct 13q haplotypes segregated within the pedigree.

ISSN: 1756-0500