Analysis of the MTHFR C677T variant with migraine phenotypes

BMC Research Notes

Table 1 Chi square analysis of MTHFR genotype for individuals experiencing clinical variables versus all migraineurs who do not.

Clinical variables	Pearson's chi-square	N	P-value
Migraine Subtype Diagnosis	16.65		< 0.001
Visual disturbances	5.57	96	0.062
Numbness & Tingling	1.49	45	0.475
Speech problems	1.41	26	0.493
Nausea	0.15	165	0.927
Emesis	0.69	121	0.708
Diarrhoea	2.3	18	0.316
Phonophobia	2.16	153	0.34
Photophobia	0.85	177	0.654
osmophobia	3.78	42	0.151
Altered Vision	0.52	81	0.77
Dizziness/Double Vision	4.33	49	0.115
Speech problems	1.78	31	0.411
Numbness & Tingling	0.1	49	0.952
Weakness	2.7	54	0.259
Pulsating & throbbing head pain	1.23	158	0.542
Unilateral head pain	7.07	123	0.029
Bilateral head pain	2.76	66	0.251
Head movement discomfort	2.72	123	0.257
Eye Movement discomfort	3.59	97	0.166
Physical Activity discomfort	8.97	149	0.011
Migraine triggers
Menses	1.224	58	0.542
Weather Changes	0.98	36	0.613
Stress	7.3	123	0.026
Holiday & Relaxation	3.29	17	0.193
Red Wine	2.5	33	0.286
Other Alcohol	1.48	35	0.478
Chocolate	0.5	46	0.799
Oranges	0.21	23	0.902
Ripe Cheese	4.32	23	0.115
Migraine treatment
Yes/No	0.04	58	0.981
5-HT1 Drugs	0.03	30	0.985
5-HT1 Drug treatment effectiveness	1.97	21	0.373
Pain killers	5.02	137	0.081
Natural remedy	1.77	27	0.412
Medication for nausea	2.75	31	0.253
Treatment for other conditions/pains
Yes/No	0.67	17	0.716
Chronic neck pain	1.98	33	0.372
High blood pressure	0.08	16	0.916
Stroke	0.93	1	0.629
Heart Disease	1.5	7	0.473
Depression	1.68	23	0.431
Anxiety disorder	0.32	2	0.853
Panic disorder	0.21	6	0.899
Chronic fatigue	1.71	5	0.425
Irritable bowel	3.22	15	0.2
Menstrual problems	1.19	14	0.551
Chronic back pain	0.95	1	0.623
Contraceptive Pill	0.177	67	0.915
Passive Smoking	0.1	81	0.952

ISSN: 1756-0500