Association of 25-hydroxyvitamin D deficiency with NT-pro BNP levels in patients with acute myocardial infarction: a cross-sectional analysis
© Wetmore et al; licensee BioMed Central Ltd. 2011
Received: 28 October 2011
Accepted: 15 December 2011
Published: 15 December 2011
Nutritional vitamin D deficiency is an emerging risk factor for acute myocardial infarction (AMI) and heart failure. The association of 25-hydroxyvitamin D levels with N-terminal pro B-type natriuretic peptide (NT-proBNP), a robust prognostic marker for post-AMI mortality and heart failure, is unknown and could illuminate a potential pathway for adverse outcomes among post-AMI patients with 25-hydroxyvitamin D deficiency.
In a cross-sectional analysis, we studied 238 AMI patients from 21 U.S. centers to test the association of nutritional vitamin D (25-hydroxyvitamin D [25(OH)D]) deficiency with NT-proBNP levels. Levels of 25(OH)D levels were categorized as normal (≥30 ng/mL), insufficient (>20 - <30 ng/mL), deficient (>10 - ≤20 ng/mL), or severely deficient (≤10 ng/mL).
Low 25(OH)D levels were found in 95.7% of AMI patients. No significant trends for higher mean baseline log NT-proBNP levels in severely deficient (6.9 ± 1.3 pg/mL), deficient (6.9 ± 1.2 pg/mL), and insufficient (6.9 ± 0.9 pg/ml) groups were observed as compared with patients having normal (6.1 ± 1.7 pg/mL) levels, P = 0.17. Findings were similar in the subset of patients who had follow-up NT-proBNP levels drawn at one month. In multivariate regression modeling, after adjusting for multiple covariates, 25(OH)D was not associated with NT-proBNP.
Potential associations between nutritional vitamin D deficiency and prognosis in the setting of AMI are unlikely to be mediated through NT-proBNP pathways. Future studies should examine other mechanisms, such as inflammation and vascular calcification, by which 25(OH)D deficiency could mediate adverse outcomes post-AMI.
KeywordsVitamin D N-terminal proBNP Acute myocardial infarction
Deficiency in nutritional vitamin D [25-hydroxyvitamin D, or 25(OH)D] is highly prevalent, occurring in approximately 30%-50% of the general population [1, 2] and in an even greater percentage of hospitalized patients . In several studies, 25(OH)D deficiency has been independently associated with both incident acute myocardial infarction (AMI) and heart failure (HF) [4, 5], suggesting that 25(OH)D plays an important role in cardiac function. In support of this hypothesis, several in vitro studies have shown that calcitriol (1,25(OH)2D3), an active form of vitamin D, regulates intracellular calcium metabolism and myocardial contractility through specific vitamin D receptors on cardiac myocytes [5–8]. Consequently, 25(OH)D deficiency has been associated with aberrant cardiac contractility, cardiomegaly, and increased ventricular mass due to myocardial collagen deposition [6, 7], independent of its known effects on blood pressure . In studies of experimental animals, activation of nuclear vitamin D receptors by 1,25(OH)2D3 suppresses the expression and secretion of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in cardiac myocytes [9–13], while in clinical studies of nondialysis chronic kidney disease patients, individuals treated with 1,25(OH)2D3 for 12 weeks were observed to have improved left ventricular diastolic function as compared with placebo . Collectively, these findings suggest that low circulating levels of 25(OH)D could contribute to, or potentiate, the development of left ventricular dysfunction and HF after AMI.
In recent years, N-terminal pro B-type natriuretic peptide (NT-proBNP), a prohormone of BNP released from cardiac ventricles, has been associated with the severity of left ventricular dilatation and dysfunction after AMI [15, 16]. In addition, NT-proBNP is a sensitive and robust prognostic biomarker of mortality in AMI [15, 17–19], HF [20, 21] and chronic hemodialysis patients [22, 23]. Moreover, NT-proBNP levels have direct clinical implications, as they are used to guide therapeutic interventions in HF patients and lead to improved outcomes as compared with routine clinical treatment .
While both 25(OH)D and NT-proBNP are known to be associated with LV dysfunction after AMI, it is not known whether there is a correlation between levels of 25(OH)D and NT-proBNP in this setting. In clinical studies, inverse associations between 25(OH)D levels and NT-proANP in HF  and between 25(OH)D and BNP in dialysis patients have been reported [25, 26]. However, these studies had small sample sizes and were not based on patients living in the U.S., where better nutrition and fortification of milk is common . Given the adverse health implications of 25(OH)D deficiency and the lack of studies in AMI patients (a particularly high-risk group), we sought to examine the association of 25(OH)D deficiency with NT-proBNP levels in a multicenter cohort of AMI patients. Discovery of an association between circulating levels of 25(OH)D and NT-proBNP would not only suggest a potential pathway for adverse outcomes among post-AMI patients with 25(OH)D deficiency, but could also identify a potentially novel therapeutic target (i.e., nutritional vitamin D supplementation) to reduce NT-proBNP levels, in the hopes of improving prognosis after AMI.
The present study is a cross-sectional analysis of a longitudinal cohort study. Participants were drawn from the TRIUMPH (Translational Research Investigating Underlying disparities in recovery from acute Myocardial infarction: Patients' Health status) study, a prospective multicenter cohort study of AMI patients across 21 U.S. centers . Patients were eligible for TRIUMPH if they were ≥ 18 years of age and had a diagnosis of AMI. AMI was diagnosed by the presence of either a CK-MB elevation greater than twice normal or a troponin-I elevation of >0.1 mg/ml within 24 h of arrival to the hospital, accompanied by a clinical presentation suggestive of an AMI (e.g., prolonged ischemic signs or chest pain symptoms, at least one EKG with ST-wave elevation or ST-wave depression in 2 or more consecutive leads, and no alternative explanation for the presence of elevated serum cardiac markers). Patients were excluded if they transferred to the participating hospital from another facility greater than 24 h after their original AMI presentation, if they refused or could not provide informed consent, or if they were receiving hospice care. For this study, we included the last 250 TRIUMPH patients, in each of whom 25(OH)D levels were assessed in addition to the standard data collected . TRIUMPH complied with the principles of the Declarations of Helsinki and was approved by the institutional review board at the coordinating center, Mid America Heart Institute at St. Luke's Hospital (Kansas City, MO). Written informed consent was obtained from all participants.
During index hospitalization, trained data collectors performed a patient interview and detailed chart abstraction within 24-72 h of admission. Patient data at AMI presentation, including demographic features, socioeconomic status, comorbidities, severity of AMI (ST elevation present or not), Killip class, Rose dyspnea index, vital signs, and laboratory values were abstracted. The Rose dyspnea score is a validated self-reported question in AMI patients that is scored from 0-4, with higher scores indicating worse dyspnea . Regional and seasonal data were collected, given their association with 25(OH)D levels [31, 32]. Patients were classified by their residing states in to 5 U.S. geographic regions, namely northeast (NE), southeast (SE), southwest (SW), midwest (MW) and west (W). Months of April-June, July-August and September-December were classified as summer, fall, and early winter seasons, respectively.
Left ventricular systolic function (LVSF) was classified as normal, mild, moderate or severe as assessed by echocardiography, angiography or nuclear imaging and documented in the hospital record. Finally, reperfusion therapy (percutaneous intervention [PCI] and/or coronary artery bypass surgery [CABG]) and other acute therapies, as well as medications prescribed at hospital discharge, were recorded. Blood samples from all consenting patients were sent to a core laboratory (Clinical Reference Laboratories, Lenexa, KS, USA) for NT-proBNP measurement (Roche Diagnostics, Indianapolis, IN, USA) and 25(OH)D assays, as described below.
An in vitro radioimmunoassay assay (DiaSorin, Stillwater, MN, USA) was used for quantitative determination of 25(OH)D and other hydroxylated vitamin D metabolites in human serum. The DiaSorin 25(OH)D assay comprises a two-step procedure involving both a rapid extraction of 25(OH)D and other hydroxylated metabolites from serum or plasma with acetonitrile along with a 25(OH)D-specific antibody and tracer, and phase separation with a second antibody-precipitating complex. The total (intra-and inter-assay) precision of the assay has a coefficient of variation (CV) of 9.4% and 11% for control values of 8.6 ng/mL and 49.0 ng/ml, respectively.
For measurement of circulating NT-proBNP levels, the Roche electro-chemiluminescence immunoassay for the in vitro quantization was used (ECLIA Roche diagnostics, Mannheim, Germany). The precision of this assay was represented by a CV of 3.2% and 2.3% for control values of 175 pg/mL and 4962 pg/mL, respectively. Blood samples for NT-proBNP were drawn immediately prior to hospital discharge. The mean time of the NT-proBNP blood draw was 3.5 ± 4 days after enrollment. Glomerular filtration rate (eGFR) was estimated using the four variable Modification of Diet in Renal Disease (MDRD) study equation .
Participants were classified into clinically-relevant categories on the basis of 25(OH)D levels. Patients with levels ≥30 ng/mL were classified as normal, while levels >20 ng/mL and <30 ng/ml were considered insufficient, levels of >10 to ≤20 ng/ml were deficient, and levels ≤10 ng/mL were severely deficient. Median NT-proBNP levels were compared using the non-parametric Kruskal-Wallis test, due to the positively-skewed distribution of NT-proBNP. Log NT-proBNP and quartiles of NT-proBNP were compared across the four 25(OH)D strata using ANOVA and chi-square tests, respectively, both at baseline and, in a complementary analysis, in the subgroup of patients who had 1-month levels of NT-proBNP levels drawn. To confirm previously-reported relationships, log NT-proBNP and category of LVSF was analyzed with the linear trend test. Spearman rank correlation was obtained between NT-proBNP and 25(OH)D levels. Multivariable linear regression analysis to determine the association of 25(OH)D levels with log NT-proBNP was performed, adjusting for relevant covariates and confounders. The presence of a potential interaction between NT-proBNP levels and type of AMI (i.e., ST-elevation versus non-ST-elevation) was formally tested using the likelihood ratio test. A P- value of <0.05 was considered statistically significant. All analyses were conducted using SAS v9.1 software (Cary, NC, U.S.).
Of the 238 enrolled patients on whom sufficient data was available, the median 25(OH)D concentration was 16 ng/mL (interquartile range [IQR], 12-21 ng/mL). As noted previously , classification of 25(OH)D levels into more clinically-interpretable ranges showed 40 (16.8%) to be severely deficient, 138 (57.9%) to be deficient, and 50 (21.0%) to be insufficient. Only 4.2% of participants in the study had normal 25(OH)D levels, with none of the African-American participants having normal levels.
Baseline characteristics of study participants, by 25(OH)D group
25(OH)D group, ng/mL
( n = 40)
( n = 138)
( n = 50)
( n = 10)
55.0 ± 11.2
57.8 ± 11.8
58.8 ± 10.2
62.4 ± 11.3
Male, n (%)
Caucasian, n (%)
32.1 ± 5.6
30.9 ± 6.9
29.5 ± 5.6
26.5 ± 4.6
Low social support, n (%)
No health insurance, n (%)
Smoked within 1 month, n (%)
Leisure time activity, n (%)
Geographical region, n (%)
Season, n (%)
Comorbidities, n (%)
Chronic heart failure
LVH on admission ECG, n (%)
Killip class on arrival, n (%)
Rose dyspnea score
1.0 ± 0.9
0.9 ± 0.9
0.8 ± 0.8
0.6 ± 1.0
Final MI diagnosis, n (%)
LV systolic function, n (%)
Troponin I (ng/ml)
1.7 ± 1.8
1.6 ± 1.7
0.7 ± 1.2
Total Cholesterol (mg/dl)
150.6 ± 47
157.3 ± 29
150.5 ± 29
189.7 ± 47
37.9 ± 10.6
38.4 ± 8.7
40.6 ± 10.7
43.1 ± 25.2
92.2 ± 36.7
97.4 ± 25
90.4 ± 25.7
119.2 ± 42.8
153.2 ± 74
185.6 ± 145
143.6 ± 79
195.4 ± 169
8.9 ± 0.6
8.8 ± 0.6
9.0 ± 0.4
9.3 ± 0.6
Intact PTH (pg/ml)
59.8 ± 67.7
40.1 ± 28.1
32.8 ± 15.3
32.0 ± 26.5
3.6 ± 0.7
3.5 ± 0.8
3.5 ± 0.7
3.7 ± 0.9
5.2 ± 5.6
3.8 ± 5.3
3.8 ± 4.5
0.9 ± 0.8
eGFR, mL/min/1.73 m2
84.7 ± 28.1
88.3 ± 27.3
80.3 ± 18.9
80.1 ± 18.8
ACEI/ARB, n (%)
Diuretic, n (%)
Omega-3 supplements, n (%)
Continuous data shown as mean ± 1 standard deviation. 25(OH)D, 25-hydroxyvitamin D; BMI, body mass index; MI, myocardial infarction; CKD, chronic kidney disease; LVH, left ventricular hypertrophy; ECG, electrocardiogram; MI, myocardial infarction; STEMI, ST-segment elevation myocardial infarction; LV, left ventricular; HDL, high density lipoprotein; LDL, low density lipoprotein; PTH, parathyroid hormone; hs-CRP, high sensitivity C-reactive protein; eGFR, estimated glomerular filtration rate; ACEI, angiotensin converting enzyme inhibitor; ARB, angiotensin receptor blocker.
To confirm the existence of the expected association of LVSF with NT-proBNP levels, we examined this relationship in terms of both absolute and log-transformed baseline NT-proBNP levels. There was a significant graded association: individuals with normal LVSF had a mean baseline NT-proBNP level of 1296 pg/mL; those with mildly-decreased LVSF, 1833 pg/mL; those with moderately-decreased LVSF, 4461 pg/mL; and those with severely-decreased LVSF, 5776 pg/mL (P < 0.001 in the cases of both log-transformed and untransformed NT-proBNP levels).
Association of 25(OH)D levels with NT-proBNP levels
25(OH)D level, ng/mL
(n = 40)
(n = 138)
(n = 50)
(n = 10)
Median NT-proBNP (pg/mL)
Mean log NT-pro BNP
6.9 ± 1.3
6.9 ± 1.2
6.9 ± 0.9
6.1 ± 1.7
NT-pro BNP (pg/mL), n (%)
Quartile 1 (5 to <488), 58 (24.3)
Quartile 2 (488 to <924.5), 61(25.6)
Quartile 3 (924.5 to <1882), 59 (24.7)
Quartile 4 (1882 to 31230), 60 (25.2)
Continuous data shown as mean ± 1 standard deviation. 25(OH)D, 25-hydroxyvitamin D; NT-proBNP, N terminal pro brain natriuretic peptide
Because NT-proBNP levels can vary in the setting of AMI, we analyzed the subset (n = 66) of individuals who had NT-proBNP levels drawn one month after discharge. Again, there was no association between initial 25(OH)D levels and 1-month NT-proBNP levels (P = 0.82)
Multivariable regression analysis showing association of factors with NT-proBNP levels
Age, per 10-yr increment
BMI, per 5 units kg/m2 increment
Lack of social support
No health insurance
Smoked within 1 month
Season, Nov-Feb vs. Mar-Oct
History of diabetes
History of prior MI
hs-CRP, per 5 units mg/L increment
eGFR, per 5 units mL/min increment
25(OH)D, per 10 ng/mL increment
BMI, body mass index; MI, myocardial infarction; PCI, percutaneous coronary intervention; CABG, coronary artery bypass graft; hs-CRP, high sensitivity C-reactive protein; eGFR, estimated glomerular filtration rate; 25(OH)D, 25-hydroxyvitamin D
Finally, we considered the theoretical possibility that our results might be affected by type of AMI (ST-elevation versus non-ST-elevation), so we formally tested for an interaction between type of AMI and NT-proBNP levels; none was found (P = 0.2)
In this cross-sectional observational study, we found no evidence of an association between levels of 25(OH)D and NT-proBNP upon discharge, nor was there evidence of an association at one month in the subset of tested patients. To our knowledge, this is the first study to examine levels 25(OH)D and NT-proBNP in an AMI population. Thus, while both 25(OH)D and NT-proBNP levels are associated with cardiovascular disease and heart failure, they appear to impact prognosis through different mechanisms in the setting of AMI. However, we extend our previous findings  in this AMI cohort by showing that 25(OH)D levels are associated with smoking, lower degrees of physical activity, and lesser use of omega-3 supplements in bivariate analysis, consistent with previous reports [1, 31, 35]. That low social support and lack of medical insurance were associated in a graded manner across fine categories of 25(OH)D level suggest that these factors, both of which are associated with higher morbidity and mortality after MI [36–38], should be investigated in more depth in future. Additionally, although our data do not support an independent association between 25(OH)D deficiency and a biomarker of left ventricular dysfunction, namely NT-proBNP, in the setting of AMI, the high prevalence of 25(OH)D deficiency, which has been associated with incident MI  in prior observational studies, is an important area of future investigation. It would be critical to examine, for instance, whether rectifying low nutritional vitamin D levels in post-AMI patients is associated with an improvement in long-term outcomes.
Our findings extend and confirm insights provided by Pilz et al., who studied patients with established CAD referred to coronary angiography . While these investigators found that 25(OH)D deficiency was significantly associated with higher New York Heart Association functional HF classes in unadjusted analysis, this association was no longer significant after adjustment for other clinical variables. In contrast, our findings are somewhat dissimilar from prior observations in chronic hemodialysis patients, where lower 25(OH)D levels were found to be associated with significantly higher log BNP levels . NT-proBNP is a more stable form of BNP and correlates well with BNP levels in HF patients . Similar reports in chronic HF patients have also suggested an inverse, nonlinear association between 25(OH)D and NT-proANP levels , although a clinical trial of nutritional vitamin D supplementation failed to alter patients' NT-proBNP levels .
More recently, a large cohort of patients referred to coronary angiography in the LUdgwigshafen RIsk and Cardiovascular Health (LURIC) study suggested that 25(OH)D levels remained independently associated with NT-proBNP levels in a multivariable model (β = -0.180, P<0.001) . It is unknown whether the discrepancy in our findings and those of previous studies is due to unmeasured confounding in prior reports, or to the impact of acute myocardial injury (present in all participants of our study) on NT-proBNP levels [42, 43]. Acute effects of MI could overwhelm or mask the basal association of 25(OH)D with NT-proBNP found in a more stable condition (such as that of the participants of the LURIC study), given that NT-proBNP levels are influenced by acute ischemia  and can change over time . We did, however, specifically examine the association of 25(OH)D levels and 1-month NT-proBNP levels in a subset of patients and found results similar to our primary analysis of baseline (hospital discharge) NT-proBNP levels, suggesting that volatility in NT-proBNP levels in the setting of AMI may not be responsible for our findings.
The results of our study should be interpreted in the context of some limitations. Our sample size was small, and therefore was underpowered for some analyses. However, our study of 238 patients did have 80% power to observe an unadjusted correlation of 0.18 between 25(OH)D and NT-proBNP levels (a level comparable to that of the LURIC study). Nevertheless, we cannot of course be entirely certain of our findings, so more work in this regard must be performed. Additionally, there were very few patients (n = 10) who had normal 25(OH)D levels, and if there is a non-linear association between outcome and normal 25(OH)D levels, we may have been underpowered to detect this. It is also possible that the association between the biomarkers we tested might have been stronger at a time of clinical stability or, conversely, at the time of acute presentation, since our samples for both 25(OH)D and NT-proBNP were taken prior to discharge; however the prognostic importance of NT-proBNP at the time of MI has consistently been shown to be strong [18, 19], and we performed the 1-month analysis to increase confidence in our findings.
In conclusion, the mechanism by which nutritional vitamin D deficiency mediates outcomes in AMI patients does not appear to be through its effects on, or a relationship with, NT-proBNP. Future studies should better clarify the clinical mechanism by which 25(OH)D deficiency is associated with outcomes in AMI patients. Potential candidates might include more long-term processes such as inflammation and vascular calcification. While we did not observe an association between levels of 25(OH)D and NT-proBNP, we did find a remarkably high frequency of 25(OH)D deficiency among AMI patients, consistent with other reports of hospitalized patients . Hospitalization for AMI offers clinicians an opportunity to not only identify modifiable risk factors and to optimize medications for secondary prevention, but also to address other comorbidities, such as 25(OH)D deficiency. Given that nutritional vitamin D is readily available, inexpensive, and has a good safety profile, future studies should investigate whether addressing 25(OH)D deficiency might improve outcomes in AMI patients, regardless of the mechanism of its known association with post-AMI risk.
- 25 (OH)D:
Acute myocardial infarction
Atrial natriuretic peptide
Brain natriuretic peptide
Coronary artery bypass surgery
Coronary artery disease
Estimated glomerular filtration rate
High sensitivity C-reactive protein
Left ventricular dysfunction
Modification of Diet in Renal Disease
N-terminal pro B-type natriuretic peptide
Parathyroid hormone levels
Translational Research Investigating Underlying disparities in recovery from acute Myocardial infarction: Patients' Health status
Vascular smooth muscle cell.
TRIUMPH was supported by the NHLBI Specialized Center of Clinically Oriented Research in Cardiac Dysfunction and Disease (grant no. P50 HL077113) and Cardiovascular Outcomes, Inc, Kansas City, Missouri. Dr. Gadi was supported by a Genzyme, Inc, research fellowship award. The authors thank Connie Wang, MD, for technical assistance in the preparation of the manuscript.
- Lee JH, O'Keefe JH, Bell D, Hensrud DD, Holick MF: Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor?. J Am Coll Cardiol. 2008, 52: 1949-1956.PubMedView ArticleGoogle Scholar
- Martins D, Wolf M, Pan D, Zadshir A, Tareen N, Thadhani R, Felsenfeld A, Levine B, Mehrotra R, Norris K: Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2007, 167: 1159-1165.PubMedView ArticleGoogle Scholar
- Thomas MK, Lloyd-Jones DM, Thadhani RI, Shaw AC, Deraska DJ, Kitch BT, Vamvakas EC, Dick IM, Prince RL, Finkelstein JS: Hypovitaminosis D in medical inpatients. N Engl J Med. 1998, 338: 777-783.PubMedView ArticleGoogle Scholar
- Giovannucci E, Liu Y, Hollis BW, Rimm EB: 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med. 2008, 168: 1174-1180.PubMedPubMed CentralView ArticleGoogle Scholar
- Zittermann A, Schleithoff SS, Tenderich G, Berthold HK, Korfer R, Stehle P: Low vitamin D status: a contributing factor in the pathogenesis of congestive heart failure?. J Am Coll Cardiol. 2003, 41: 105-112.PubMedView ArticleGoogle Scholar
- Weishaar RE, Kim SN, Saunders DE, Simpson RU: Involvement of vitamin D3 with cardiovascular function. III. Effects on physical and morphological properties. Am J Physiol. 1990, 258: E134-142.PubMedGoogle Scholar
- Weishaar RE, Simpson RU: Involvement of vitamin D3 with cardiovascular function. II. Direct and indirect effects. Am J Physiol. 1987, 253: E675-683.PubMedGoogle Scholar
- Zittermann A, Schleithoff SS, Koerfer R: Vitamin D insufficiency in congestive heart failure: why and what to do about it?. Heart Fail Rev. 2006, 11: 25-33.PubMedView ArticleGoogle Scholar
- The World Health Organization MONICA Project (monitoring trends and determinants in cardiovascular disease): a major international collaboration. WHO MONICA Project Principal Investigators. J Clin Epidemiol. 1988, 41: 105-114.
- Bidmon HJ, Gutkowska J, Murakami R, Stumpf WE: Vitamin D receptors in heart: effects on atrial natriuretic factor. Experientia. 1991, 47: 958-962.PubMedView ArticleGoogle Scholar
- Chen S, Nakamura K, Gardner DG: 1,25-dihydroxyvitamin D inhibits human ANP gene promoter activity. Regul Pept. 2005, 128: 197-202.PubMedView ArticleGoogle Scholar
- Weishaar RE, Simpson RU: The involvement of the endocrine system in regulating cardiovascular function: emphasis on vitamin D3. Endocr Rev. 1989, 10: 351-365.PubMedView ArticleGoogle Scholar
- Wu J, Garami M, Cao L, Li Q, Gardner DG: 1,25(OH)2D3 suppresses expression and secretion of atrial natriuretic peptide from cardiac myocytes. Am J Physiol. 1995, 268: E1108-1113.PubMedGoogle Scholar
- Singh NP, Sahni V, Garg D, Nair M: Effect of pharmacological suppression of secondary hyperparathyroidism on cardiovascular hemodynamics in predialysis CKD patients: A preliminary observation. Hemodial Int. 2007, 11: 417-423.PubMedView ArticleGoogle Scholar
- Bettencourt P, Ferreira A, Pardal-Oliveira N, Pereira M, Queiros C, Araujo V, Cerqueira-Gomes M, Maciel MJ: Clinical significance of brain natriuretic peptide in patients with postmyocardial infarction. Clin Cardiol. 2000, 23: 921-927.PubMedView ArticleGoogle Scholar
- Crilley JG, Farrer M: Left ventricular remodelling and brain natriuretic peptide after first myocardial infarction. Heart. 2001, 86: 638-642.PubMedPubMed CentralView ArticleGoogle Scholar
- Morrow DA, Braunwald E: Future of biomarkers in acute coronary syndromes: moving toward a multimarker strategy. Circulation. 2003, 108: 250-252.PubMedView ArticleGoogle Scholar
- Omland T, Aakvaag A, Bonarjee VV, Caidahl K, Lie RT, Nilsen DW, Sundsfjord JA, Dickstein K: Plasma brain natriuretic peptide as an indicator of left ventricular systolic function and long-term survival after acute myocardial infarction. Comparison with plasma atrial natriuretic peptide and N-terminal proatrial natriuretic peptide. Circulation. 1996, 93: 1963-1969.PubMedView ArticleGoogle Scholar
- Omland T, de Lemos JA, Morrow DA, Antman EM, Cannon CP, Hall C, Braunwald E: Prognostic value of N-terminal pro-atrial and pro-brain natriuretic peptide in patients with acute coronary syndromes. Am J Cardiol. 2002, 89: 463-465.PubMedView ArticleGoogle Scholar
- Bayes-Genis A, Lopez L, Zapico E, Cotes C, Santalo M, Ordonez-Llanos J, Cinca J: NT-ProBNP reduction percentage during admission for acutely decompensated heart failure predicts long-term cardiovascular mortality. J Card Fail. 2005, 11: S3-8.PubMedView ArticleGoogle Scholar
- Januzzi JL, van Kimmenade R, Lainchbury J, Bayes-Genis A, Ordonez-Llanos J, Santalo-Bel M, Pinto YM, Richards M: NT-proBNP testing for diagnosis and short-term prognosis in acute destabilized heart failure: an international pooled analysis of 1256 patients: the International Collaborative of NT-proBNP Study. Eur Heart J. 2006, 27: 330-337.PubMedView ArticleGoogle Scholar
- Madsen LH, Ladefoged S, Corell P, Schou M, Hildebrandt PR, Atar D: N-terminal pro brain natriuretic peptide predicts mortality in patients with end-stage renal disease in hemodialysis. Kidney Int. 2007, 71: 548-554.PubMedView ArticleGoogle Scholar
- Roberts MA, Srivastava PM, Macmillan N, Hare DL, Ratnaike S, Sikaris K, Ierino FL: B-type natriuretic peptides strongly predict mortality in patients who are treated with long-term dialysis. Clin J Am Soc Nephrol. 2008, 3: 1057-1065.PubMedPubMed CentralView ArticleGoogle Scholar
- Troughton RW, Frampton CM, Yandle TG, Espiner EA, Nicholls MG, Richards AM: Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations. Lancet. 2000, 355: 1126-1130.PubMedView ArticleGoogle Scholar
- Matias PJ, Ferreira C, Jorge C, Borges M, Aires I, Amaral T, Gil C, Cortez J, Ferreira A: 25-Hydroxyvitamin D3, arterial calcifications and cardiovascular risk markers in haemodialysis patients. Nephrol Dial Transplant. 2009, 24: 611-618.PubMedView ArticleGoogle Scholar
- Obineche EN, Saadi H, Benedict S, Pathan JY, Frampton CM, Nicholls MG: Interrelationships between B-type natriuretic peptides and vitamin D in patients on maintenance peritoneal dialysis. Perit Dial Int. 2008, 28: 617-621.PubMedGoogle Scholar
- Moore C, Murphy MM, Keast DR, Holick MF: Vitamin D intake in the United States. J Am Diet Assoc. 2004, 104: 980-983.PubMedView ArticleGoogle Scholar
- Arnold SV, Chan PS, Jones PG, Decker C, Buchanan DM, Krumholz HM, Ho PM, Spertus JA: Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status (TRIUMPH): design and rationale of a prospective multicenter registry. Circ Cardiovasc Qual Outcomes. 4: 467-476.
- Lee JH, Gadi R, Spertus JA, Tang F, O'Keefe JH: Prevalence of vitamin D deficiency in patients with acute myocardial infarction. Am J Cardiol. 107: 1636-1638.
- Arnold SV, Spertus JA, Jones PG, Xiao L, Cohen DJ: The impact of dyspnea on health-related quality of life in patients with coronary artery disease: results from the PREMIER registry. Am Heart J. 2009, 157: 1042-1049. e1041PubMedView ArticleGoogle Scholar
- Melamed ML, Michos ED, Post W, Astor B: 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med. 2008, 168: 1629-1637.PubMedPubMed CentralView ArticleGoogle Scholar
- Zittermann A, Schleithoff SS, Koerfer R: Putting cardiovascular disease and vitamin D insufficiency into perspective. Br J Nutr. 2005, 94: 483-492.PubMedView ArticleGoogle Scholar
- Rossetti E, Mariani M, Poli A, Palmerini T, Finazzi S, Lotzniker M, Sangiorgi D, De Servi S: NT pro-B-type natriuretic peptide levels are related to microvascular reperfusion in patients undergoing direct percutaneous transluminal coronary angioplasty for anterior ST-segment elevation myocardial infarction. J Cardiovasc Med (Hagerstown). 11: 359-364.
- Murthy K, Stevens LA, Stark PC, Levey AS: Variation in the serum creatinine assay calibration: a practical application to glomerular filtration rate estimation. Kidney Int. 2005, 68: 1884-1887.PubMedView ArticleGoogle Scholar
- Wang TJ, Pencina MJ, Booth SL, Jacques PF, Ingelsson E, Lanier K, Benjamin EJ, D'Agostino RB, Wolf M, Vasan RS: Vitamin D deficiency and risk of cardiovascular disease. Circulation. 2008, 117: 503-511.PubMedView ArticleGoogle Scholar
- Burg MM, Barefoot J, Berkman L, Catellier DJ, Czajkowski S, Saab P, Huber M, DeLillo V, Mitchell P, Skala J, et al: Low perceived social support and post-myocardial infarction prognosis in the enhancing recovery in coronary heart disease clinical trial: the effects of treatment. Psychosom Med. 2005, 67: 879-888.PubMedView ArticleGoogle Scholar
- Mookadam F, Arthur HM: Social support and its relationship to morbidity and mortality after acute myocardial infarction: systematic overview. Arch Intern Med. 2004, 164: 1514-1518.PubMedView ArticleGoogle Scholar
- Rahimi AR, Spertus JA, Reid KJ, Bernheim SM, Krumholz HM: Financial barriers to health care and outcomes after acute myocardial infarction. Jama. 2007, 297: 1063-1072.PubMedView ArticleGoogle Scholar
- Pilz S, Marz W, Wellnitz B, Seelhorst U, Fahrleitner-Pammer A, Dimai HP, Boehm BO, Dobnig H: Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography. J Clin Endocrinol Metab. 2008, 93: 3927-3935.PubMedView ArticleGoogle Scholar
- Mueller T, Gegenhuber A, Poelz W, Haltmayer M: Head-to-head comparison of the diagnostic utility of BNP and NT-proBNP in symptomatic and asymptomatic structural heart disease. Clin Chim Acta. 2004, 341: 41-48.PubMedView ArticleGoogle Scholar
- Schleithoff SS, Zittermann A, Tenderich G, Berthold HK, Stehle P, Koerfer R: Vitamin D supplementation improves cytokine profiles in patients with congestive heart failure: a double-blind, randomized, placebo-controlled trial. Am J Clin Nutr. 2006, 83: 754-759.PubMedGoogle Scholar
- de Lemos JA, Morrow DA: Brain natriuretic peptide measurement in acute coronary syndromes: ready for clinical application?. Circulation. 2002, 106: 2868-2870.PubMedView ArticleGoogle Scholar
- Morrow DA, de Lemos JA, Sabatine MS, Murphy SA, Demopoulos LA, DiBattiste PM, McCabe CH, Gibson CM, Cannon CP, Braunwald E: Evaluation of B-type natriuretic peptide for risk assessment in unstable angina/non-ST-elevation myocardial infarction: B-type natriuretic peptide and prognosis in TACTICS-TIMI 18. J Am Coll Cardiol. 2003, 41: 1264-1272.PubMedView ArticleGoogle Scholar
- Mistry N, Abdelnoor M, Seljeflot I, Hoffmann P, Bohmer E, Bjornerheim R, Kjeldsen SE, Halvorsen S: Amino-terminal pro-B-type natriuretic peptide (NT-proBNP) levels 3 months after myocardial infarction are more strongly associated with magnetic resonance-determined ejection fraction than NTproBNP levels in the acute phase. J Card Fail. 17: 479-486.
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