Inherited common variants in mitochondrial DNA and invasive serous epithelial ovarian cancer risk

BMC Research Notes

Table 3 MT-SNP-invasive serous ovarian cancer risk association results (MT-SNPs MAF >5%)

SNP	ID	BP	Major/minor allele	Case/control MAF	N	OR (95% CI)	P	P _emp
rs2853517	mt709	709	G/A	0.167 / 0.153	830	1.10 (0.76-1.60)	0.61	0.86
rs41352944	mt930	930	C/T	0.056 / 0.043	831	1.30 (0.69-2.46)	0.41	0.55
rs28358571	mt1189	1189	T/C	0.077 / 0.077	831	0.98 (0.59-1.64)	0.94	1.00
rs3928306	mt3010	3010	C/T	0.209 / 0.212	831	1.01 (0.72-1.41)	0.96	1.00
rs2015062	mt7028	7028	A/G	0.408 / 0.428	831	0.93 (0.70-1.23)	0.60	0.64
rs2853825	mt9477	9477	G/A	0.105 / 0.084	830	1.27 (0.80-2.04)	0.31	0.38
rs2853495	mt11719	11719	A/G	0.457 / 0.456	831	1.01 (0.76-1.33)	0.97	1.00
rs3088053	mt11812	11812	A/G	0.079 / 0.075	831	1.06 (0.63-1.78)	0.82	0.73
rs2853499	mt12372	12372	C/T	0.249 / 0.239	825	1.05 (0.76-1.45)	0.77	0.86
rs2854122	mt12705	12705	G/A	0.097 / 0.097	795	1.01 (0.63-1.62)	0.97	1.00
rs2853504	mt14793	14793	T/C	0.054 / 0.055	831	1.00 (0.54-1.82)	0.99	1.00
rs28357681	mt14798	14798	A/G	0.154 / 0.169	829	0.90 (0.62-1.31)	0.59	0.73
rs28357684	mt15043	15043	G/A	0.064 / 0.062	829	1.06 (0.60-1.88)	0.83	0.86
rs2853510	mt15924	15924	A/G	0.066 / 0.068	831	0.97 (0.56-1.68)	0.91	1.00

Sorted by mitochondrial base-pair position. ID is SNP as reported by Saxena et al., 2006, available at: http://www.broadinstitute.org/mpg/tagger/mito.html [Accessed 15 Nov, 2012]. BP, mitochondrial base-pair position according to the revised Cambridge reference sequence; MAF, minor allele frequency; N, number of observations; OR, odds ratio; 95% CI, 95% confidence interval. OR and 95% CI are for logistic regression adjusting for age at diagnosis or interview. P is the asymptotic P-value for testing MT-SNP effect significance; P_emp is empirical point-wide P-value, implement in PLINK (v1.07).

ISSN: 1756-0500