Fig. 3

Treatment of AT-Derm animals with VT ameliorates the phenotype. Wildtype or AT-Derm animals with either moderate to severe phenotype were treated with VT at 40 µg/kg every 3 days for 30 days. Skin biopsies were taken from the back prior to initiation of treatment and at the conclusion of the treatment protocol. Panels correspond to the same animals post- and pre-treatment. Note the epidermal hyperplasia (asterisk) and immune cell infiltrate, which is unchanged in animals treated with PBS alone. In contrast, animals receiving VT-treatment presented with an epidermal thickness that resembled normal WT animals either treated with PBS or VT