Table 2 Estimated current annual clinical and economic burden of HA

Bleeds (n)

40,020

20.94

20,853

6.80

5,934

3.79

26,661

13.33

3,893

4.10

45,119

9.39

3,957

3.99

16,241

10.43

IP Episodes (n)

890

0.47585

478

0.16

5,370

3.43

3,683

12.69

1,092

1.15

24,293

5.06

605

0.61

1,581

1.87

Tx Visits (n)

11,443

5.99

43,792

14.28

5,996

3.83

6,246

3.12

3,644

3.84

120,504

25.08

5,346

5.39

4,016

2.58

Px Visits (n)

32,592

17.05

21,321

6.95

5,386

3.44

19,138

9.57

8,479

8.93

43,351

9.02

13,855

11.37

2,906

1.87

Target Joints (n)

17,953

9.39

8,851

2.89

1,580

1.01

15,901

7.95

2,029

2.14

11,788

2.45

1,259

1.27

7,423

4.77

Surgeries (n)

1,585

0.83

1,726

0.56

783

0.50

463

0.23

447

0.50

597

0.12

50

0.05

99

0.06

Deaths

9

0.00

15

0.00

1

0.00

9

0.00

1

0.00

72

0.00

2

0.00

8

0.00

Missed Days

186,647

95

101,281

33.03

82,198

52.49

60,326

30.16

40,312

42.44

252,932

52.64

9,409

7.43

109,152

63.73

CFC Consumption (IU)

320.04 M

167,475

371.39 M

121,084

92.91 M

59,327

49.13 M

24,563

57.20 M

60,206

806.50 M

167,851

193.90 M

195,467

94.32 M

60,579

Costs (USD)

HCRU

2.35 M

1,232

6.16 M

2,008

0.52 M

335

1.01 M

533

3.51 M

3,690

60.46 M

12,583

4.22 M

4,256

9.45 M

6,069

Indirect

1.84 M

964

1.37 M

448

2.64 M

1,684

0.27 M

135

1.22 M

1,286

3.83 M

797

0.66 M

667

1.02 M

656

Total

4.20 M

2,196

7.53 M

2,455

3.16 M

2,019

1.33 M

667

4.73 M

4,976

64.29 M

13,380

4.88 M

4,923

10.47 M

6,725