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Table 3 Impact of change in HA management on clinical outcomes and annual costs

From: Estimating the impact of improved management of haemophilia a on clinical outcomes and healthcare utilisation and costs

Impact on outcomes with improvements in HA management

Algeria

Argentina

Chile

India

Malaysia

Mexico

Taiwan

Thailand

Total

Per switcher

Total

Per switcher

Total

Per switcher

Total

Per switcher

Total

Per switcher

Total

Per switcher

Total

Per switcher

Total

Per switcher

 

Bleeds (n)

-5,485

-26.24

-2,169

-13.82

-475

-19.00

-3,856

-13.30

-214

-10.193

-1,984

-25.44

-131

-32.75

-1,656

-12.74

IP Episodes (n)

-115

-0.55

-53

-0.34

-430

-17.20

-535

-1.84

-61

-2.903

-1,081

-13.86

-20

-5.00

-161

-1.24

Tx Visits (n)

-1,554

-7.44

-4,649

-29.61

-470

-18.80

-906

-3.12

-203

-9.67

-5,321

-68.22

-176

-44.00

-410

-3.15

Px Visits (n)

+ 9,459

45.26

+ 2,454

15.63

+ 327

13.08

+ 30,149

103.96

+ 443

+ 21.10

+ 1,013

12.99

+ 79

19.75

+ 1,694

13.03

Target Joints (n)

-2,554

-12.22

-959

-6.11

-132

-5.28

-2,316

-7.99

-130

-6.19

-538

-6.90

-41

-10.25

-764

-5.88

Surgeries (n)

-225

-1.08

-187

-1.19

-67

-2.68

-68

-0.23

-29

-1.38

-28

-0.36

-2

-0.50

-10

-0.08

Deaths

-1

0.00

-2

-0.01

-0

0.00

-1

0.00

-0

0.00

-4

-0.05

-0

0.00

-1

-0.01

Missed Days

-25,648

-123

-10,800

-69

-6,797

-272

-8,744

-30

-2,4888

-118

-11,568

-148

-312

-78

-10,126

-78

CFC Consumption (IU)

+ 17.12 M

+ 81,897

+ 3.54 M

+ 22,568

-1.46 M

-58,461

+ 6.60 M

+ 22,742

-1.69 M

-80,60

+ 9.71 M

+ 124,481

+ 0.05 M

+ 13,673

+ 0.05 M

+ 364

Costs (USD)

HCRU

-0.19 M

-888

-0.59

-3,753

-0.03

-1,087

-0.09 M

-316

-0.21 M

-9,974

2.59

-33,170

0.13

-33,334

0.68

-5,213

Indirect

-0.27 M

-1,273

-0.17

-1,088

-0.25

-10,082

-0.04 M

-139

-0.08 M

-3,823

0.21

-2,636

0.02

-5,415

0.11

-818

TOTAL

-0.45 M

-2,160

-0.76

-4,841

-0.28

-11,169

-0.13 M

-455

-0.29 M

-13,797

2.79

-35,805

0.15

-38,748

0.78

-6,031

  1. Notes Cost savings incorporate avoidance of HCRU costs associated with the long-term management of bleeds
  2. Abbreviations: CFC: clotting factor concentrates; HCRU: healthcare resource use; IP: Inpatient (hospitalisations); IU: international units; PWHA: patient with haemophilia A; Px: prophylaxis; Tx: treatment.