Effects of Doxorubicin on Extracellular Matrix Regulation in Primary Cardiac Fibroblasts from Mice

BMC Research Notes

Table 1 Differentially expressed proteins in primary cardiac fibroblasts isolated from BALB/c mice

Uniprot Accession #	Protein Description	Fold of Change
Up regulated
Q64695	Endothelial protein C receptor	3.3
P13597-2	Isoform 2 of Intercellular adhesion molecule 1	2.5
Q9JHW9	Aldehyde dehydrogenase family 1 member A3	2.4
P48999	Arachidonate 5-lipoxygenase	2.0
P16125	L-lactate dehydrogenase B chain	2.0
Q9CRC6	BLOC-1-related complex subunit 7	1.9
Q62433	Protein NDRG1	1.8
Q5I2A0	Serine protease inhibitor A3G	1.8
O35484	Antizyme inhibitor 1	1.8
Down regulated
O35988	Syndecan-4	2.5
Q3TLR7	Denticleless protein homolog	2.4
Q9DAD6	Profilin-3	2.0
Q7TPV4	Myb-binding protein 1A	2.0
Q9WTW3	Potassium voltage-gated channel subfamily E member 4	1.9
P35441	Thrombospondin-1	1.9
Q9DAM7	Transmembrane protein 263	1.8
Q8BVY0	Ribosomal L1 domain-containing protein 1	1.8
Q03350	Thrombospondin-2	1.8
P29268	Connective tissue growth factor	1.8

Cells were treated with 1 µM DOX for 24 h (n = 5; p < 0.05)
Relative protein quantification was determined using a LC–MS based quantitative proteomics approach

ISSN: 1756-0500