Fig. 2

Effect of IMQ administration on total scratching bouts and severity of psoriasis-like activity in F2RL1 rats. A Rats with total scratching bouts treated with IMQ were significantly higher than animals exposed to vehicle (n = 5/group). Rats with scratching bouts after exposure to IMQ show decreased scratching upon administration of P24E1102 at 30 mg/kg IV at Day 10 as compared with vehicle and isotype control-dosed rats (P < 0.05) (n = 5/group). B IMQ induces scratching activity, but not biting or licking. Scratching is the main activity observed. C Rats with dermatology severity symptoms of erythema, scaling and thickening of lesions after exposure to IMQ show decreased severity upon administration with P24E1102. Data is expressed as the mean (SEM). Asterisk (*) denotes P values of IMQ compared to vehicle, *P < 0.05 (Student’s t-test, followed by Mann–Whitney post-test