Imiquimod-induced pruritus in female wild-type and knockin Wistar rats: underscoring behavioral scratching in a rat model for antipruritic treatments

Table 1 Comparison of published induced inflammatory cytokines interleukin IL-6, IL-1β, IL-17A and TNF-α performed on both skin and serum samples from rat, mouse and human using a combination of ELISA methods and MSD-ECL assay methods

Cytokine	IMQ rat induced serum	IMQ mouse induced serum	Psoriasis patient serum	IMQ rat induced skin	IMQ rat induced skin
IL-1β	−	−	−	−	+
IL-6	−	−	+	−	+
IL-17A	−	−	+	−	+
TNFα	+	+	+	+	+
Detection	MSD-ECL	ELISA	ELISA/MSD-ECL	ELISA	ELISA
Tissue	Serum	Serum	Serum	Back skin	Ear skin
References	^a	[9]	[8]	[10]	[11]

ISSN: 1756-0500