Table 6 Genotype distribution and allelic frequencies of the MTHFR, PAI-1 and Factor V Leiden polymorphisms in case and control groups
Genotypes and alleles | Control group n (%) | Patient group n (%) | χ2 | P-value |
|---|---|---|---|---|
MTHFR 1298 A > C | ||||
CC | 21 (14) | 69 (46) | 0.985241 | 0.03 |
CA | 47 (31.33) | 44 (29.33) | ||
AA | 82 (54.67) | 37 (24.67) | ||
C | 89 (29.66) | 182 (60.66) | 0.992144 | 0.01 |
A | 211 (70.33) | 118 (39.33) | ||
MTHFR 677 C > T | ||||
CC | 32 (21.34) | 47 (31.33) | 0.432125 | 0.02 |
CT | 59 (39.33) | 53 (35.33) | ||
TT | 59 (39.33) | 50 (33.34) | ||
C | 123 (41) | 147 (48.99) | 0.875965 | 0.04 |
T | 177 (58.99) | 153 (51) | ||
Factor V Leiden 1691 G > A | ||||
GG | 28 (18.66) | 72 (48) | 0.954700 | 0.01 |
GA | 30 (20) | 57 (38) | ||
AA | 92 (61.34) | 21 (14) | ||
G | 86 (28.66) | 201 (67) | 0.922548 | 0.02 |
A | 214 (71.34) | 99 (33) | ||
PAI-1-844G > A | ||||
GG | 42 (28) | 27 (18) | 0.915236 | 0.02 |
GA | 61 (40.66) | 49 (32.66) | ||
AA | 47 (31.34) | 74 (49.34) | ||
G | 145 (48.33) | 103 (34.33) | 0.962145 | 0.02 |
A | 155 (51.67) | 197 (65.67) | ||