Fig. 3
Effects of silica-inhalation, HFWD-consumption, and combined exposure on bioelectric responses to ion transport inhibitors. Shown are basal and inhibitor-induced epithelial ISC responses at A 0, B 4, and C 8 weeks post-exposure. Basal and agent-induced epithelial Rt responses at D 0, E 4, and F 8 weeks. Silica reduced basal ISC at 4 weeks (B). HFWD reduced ISC responses to amiloride at 0 week (A). HFWD + SIL increased basal ISC and ISC responses to amiloride at both 0 week (A) and 4 weeks (B). Solid lines indicate significant differences between different exposure groups at a given time point. P < 0.05. n = 6–8, 7–8, 3–8 at 0, 4, and 8 weeks, respectively