Fig. 6

Effect of silica-inhalation, HFWD-consumption, and combined exposure on normalized responses to MCh. Graphs depict percent maximum responses to extraluminally applied MCh at A 0, B 4, and C 8 weeks; intraluminally applied MCh at D 0, E 4, and F 8 weeks; and intraluminal response expressed as a percentage of the extraluminal maximal contractile response to MCh at G 0, H 4, and I 8 weeks post exposure to silica. n = 5–6, 4–6, 5–7 at 0, 4, and 8 weeks, respectively