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Table 2 EC50 values from isolated, perfused trachea experiments

From: High-fat Western diet alters crystalline silica-induced airway epithelium ion transport but not airway smooth muscle reactivity

Exposure

EC50 [− log (M)]

 

EL

IL

 

0 week

Mean ± S.E.M

Mean  ±S.E.M

n

 STD + AIR

5.98 ± 0.18

2.80 ± 0.17

5

 STD + SIL

5.50 ± 0.18

2.63 ± 0.25

6

 HFWD + AIR

5.69 ± 0.54

2.81 ± 0.15

6

 HFWD + SIL

5.21 ± 0.39

2.37 ± 0.25

5

4 weeks

   

 STD + AIR

4.98 ± 0.33

2.92 ± 0.18

5

 STD + SIL

5.38 ± 0.15

2.88 ± 0.11

6

 HFWD + AIR

5.01 ± 0.46

2.35 ± 0.15

4

 HFWD + SIL

5.37 ± 1.08

2.64 ± 0.19

4

8 weeks

 STD + AIR

5.50 ± 0.18

3.03 ± 0.18

7

 STD + SIL

5.44 ± 0.09

3.20 ± 0.07

5

 HFWD + AIR

6.06 ± 0.20

3.76 ± 0.62

5

 HFWD + SIL

5.93 ± 0.21

2.97 ± 0.38

6

  1. EC50 values for extraluminal (EL) and intraluminal (IL) concentration–response curves obtained at 0, 4 and 8 weeks post-exposure to silica and or HFWD and air (control). There were no changes in either EL or IL EC50 values in response to silica, HFWD or combined exposure. n values are given for each group