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Fig. 3 | BMC Research Notes

Fig. 3

From: Chromatin accessibility analysis suggested vascular induction of the biliary epithelium via the Notch signaling pathway in the human liver

Fig. 3

Chromatin landscape of human fetal livers. (a) A representative image of the liver of mouse E12.5 embryo. Note that a hepatoblast (white arrowhead) is segregated from a vessel by a hematopoietic cell (arrow) while another hepatoblast (black arrowhead) is neighboring to a vessel. Scale bar = 25 μm. (b) UMAP clustering showed large populations of hematopoietic cells, vascular endothelial cells and hepatoblasts. (c) Feature plots for chromatin accessibility for the Notch receptors. Note that chromatin accessibility for these genes was generally low except for minor cell populations. (d) Dot plot for chromatin accessibility for the Notch receptors. (e) Feature plots for chromatin accessibility of the DSL ligands. (f) Dot plot for chromatin accessibility of the DSL ligands. Note that the vascular endothelial cells had high chromatin accessibility for JAG1, DLL1 and DLL4

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BMC Research Notes

ISSN: 1756-0500

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