The relationship between high ratios of CD4/FOXP3 and CD8/CD163 and the improved survivability of metastatic triple-negative breast cancer patients: a multicenter cohort study

Table 2 The ROC curve and cox regression analysis of the prognostic markers

Variables	ROC Curve				Univariate cox regression		Multivariate cox regression
Variables	p-value	Cut-off	Sensitivity (in %)	Specificity (in %)	HR (95% CI)	p-value	HR (95% CI)	p-value
CD4	0.067	82.2/mm³	71.4	48.9	1.935 (1.083–3.457)	0.026	1.415 (0.638–3.141)	0.393
CD8	0.028	179/mm³	58.9	61.7	1.867 (1.095–3.182)	0.022	1.621 (0.870–3.021)	0.128
CD4/FOXP3 ratio	0.023	8.63	60.0	61.4	2.020 (1.145–3.564)	0.015	1.857 (1.049–3.288)	0.034
CD8/FOXP3 ratio	0.038	26.2	60.0	61.4	1.821 (1.032–3.231)	0.039	1.467 (0.716–3.006)	0.295
CD8/CD163 ratio	0.017	0.925	64.3	63.8	2.169 (1.254–3.752)	0.006	2.089 (1.174–3.717)	0.012

ISSN: 1756-0500