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Table 2 Predictors of septic AKI, ARDS, shock, and DIC (univariate analysis)

From: Presepsin is a more useful predictor of septic AKI and ARDS for very-old sepsis patients than for young sepsis patients in ICUs: a pilot study

Variable

Over 75 group

Under 75 group

AKI (n = 20)

ARDS (n = 5)

Shock (n = 21)

DIC (n = 15)

AKI (n = 19)

ARDS (n = 8)

Shock (n = 27)

DIC (n = 15)

P value

P value

P value

P value

P value

P value

P value

P value

Age

0.150

0.835

0.7622

0.966

0.9899

0.5211

0.180

0.813

Sex

0.7411

0.6404

0.748

0.310

1.0000

1.0000

1.000

0.511

Cancer

0.7512

1.0000

1.000

0.104

0.7555

0.4307

0.754

0.532

Coronary artery disease

0.4872

1.0000

0.475

1.000

0.581

0.4787

1.000

1.000

Diabetes mellitus

0.2308

1.0000

0.596

1.000

0.034

0.6012

0.686

0.225

Hypertension

0.0648

0.3059

0.281

0.457

0.180

0.1743

0.717

1.000

Albumin

0.3603

0.0714

0.674

0.823

0.9495

0.5422

0.608

0.554

CRP

0.0212

0.1707

0.490

0.175

0.1086

0.8476

0.096

0.106

WBC

0.8221

0.5809

0.424

0.922

0.1113

0.4420

0.007

0.014

Neutrophil

0.5365

0.6381

0.675

0.727

0.2608

0.3698

0.003

0.081

Lymphocytes

0.8003

0.2607

0.010

0.342

0.4560

0.3207

0.045

0.013

Platelet count

0.1600

0.8061

0.012

0.001

0.2156

0.4232

0.030

0.000

Fibrinogen

0.6510

0.2946

0.019

0.101

0.4808

0.6076

0.041

0.113

Survival

0.0958

0.3446

0.527

0.502

0.143

0.0115

0.286

1.000

AKI

 

0.1723

0.527

0.008

 

0.0565

0.207

0.049

ARDS

0.3416

 

0.654

0.345

0.112

 

1.000

0.425

Shock

0.3431

0.6544

 

0.001

0.108

0.6888

 

0.180

DIC

0.0079

0.3446

0.001

 

0.055

0.4255

0.180

 

Presepsin on Day 1

0.023

0.011

0.766

0.043

0.0083

0.0564

0.725

0.425

Presepsin on Day 2

0.045

0.007

0.537

0.040

0.0500

0.0336

0.542

0.087

Presepsin on Day 3

0.0527

0.022

0.598

0.065

0.3111

0.1741

0.586

0.890

Presepsin on Day 5

0.0433

0.202

0.380

0.558

0.7728

0.5713

0.089

0.435

ΔPresepsin Day 2—Day 1

0.6434

0.779

0.111

0.171

0.4526

0.2937

0.220

0.058

ΔPresepsin Day 3—Day 1

0.9738

0.865

0.495

0.947

0.1734

0.4995

0.092

0.612

ΔPresepsin Day 5—Day 1

0.9292

0.111

0.684

0.110

0.3683

0.4669

0.146

0.588

GPS

0.268

0.109

0.520

0.525

0.355

0.612

0.247

0.140

NLR

0.938

0.158

0.261

0.977

0.958

0.844

0.074

0.783

PLR

0.220

0.359

1.000

0.009

0.067

0.818

0.588

0.379

PI

0.656

0.444

0.933

0.954

0.136

0.912

0.025

0.878

PNI

0.335

0.140

0.657

0.645

0.875

0.278

0.534

0.296

iPS-GPS

0.019

0.042

0.552

0.051

0.237

0.313

0.876

0.133

iPS-NLR

0.043

0.735

0.288

0.075

0.153

0.126

0.250

0.916

iPS-PLR

0.237

0.419

0.839

0.786

0.546

0.098

0.233

0.575

iPS-PI

0.007

0.225

0.348

0.039

0.020

0.568

0.675

0.749

iPS-PNI

0.211

0.301

0.102

0.432

0.006

0.706

0.548

0.721

SOFA

0.051

0.347

0.142

0.078

0.238

0.113

0.069

0.440

qSOFA

0.633

0.692

0.966

0.603

0.091

0.533

0.370

0.613

  1. AKI acute kidney injury, ARDS acute respiratory distress syndrome, DIC disseminated intravascular coagulation, CRP C-reactive protein, WBC white blood cell; GPS Glasgow Prognostic Score, NLR neutrophil to lymphocyte ratio, PLR platelet to lymphocyte ratio, PI Prognostic Index, PNI Prognostic Nutritional Index;
  2. iPS inflammation-presepsin score, SOFA Sequential Organ Failure Assessment, qSOFA quick SOFA