BALB/c Mice resist infection with Bartonella bacilliformis

BMC Research Notes

Table 1 Experiments attempting infection of BALB/c mice with viable Bartonella bacilliformis

Exp	Route	No. of Mice^a	CFU^b	Time to sacrifice	Results of H/E stain
1	i.p.	03	1.5 × 10⁸	7 days	organs normal
2	i.p.	05	1.5 × 10⁸	6, 24 hs & 14 days	organs normal
3	i.p.	05	1.5 × 10⁸	6, 24 hs & 14 days	organs normal
4	s.c.	03	4.5 × 10⁸	24 hs	skin normal
5	s.c.	02	4.5 × 10⁸	30 days	skin normal
6	s.c.	07	1.5 × 10⁸	2, 6 & 8 hs	skin normal
7	Oral	03	1.5 × 10⁸	24 hs	organs normal
8	Oral	05	1.5 × 10⁸	24 hs	organs normal
9	i.n.	04	1.5 × 10⁸	24 hs	organs normal
10	i.d.	03	4.5 × 10⁸	7 days	skin normal
11	i.d.	02	4.5 × 10⁸	30 days	skin normal
12^b	i.d.	02	3 × 10⁸	24, 48 & 72 hs	No skin changes
13^c	i.d.	02	3 × 10⁸	24, 48 & 72 hs	No skin changes

^aForty six control mice inoculated with sterile saline
^bpreviously inoculated with viable ATCC#35685
^cpreviously inoculated with viable, recently isolated B. bacilliformis from an acute phase patient

ISSN: 1756-0500