Figure 2

Conservation in KsgA and helix 44 and the 790 loop. The model of KsgA docked onto helix 44 and the 790 loop was taken from Xu et al [16]. RNA sequences that are conserved in greater than 98% of species are colored red, 90-90% in orange, and less than 90% in yellow; these sequences are present in at least 95% of organisms. White denotes sequences that are present in less than 95% of organisms. Residues in KsgA are colored by strength of alignment, with red denoting the most highly conserved regions, then orange, yellow, pale green, dark green and blue; white regions are the least conserved. Views shown in A and B are rotated approximately 180° about the vertical axis.