Table 2 TRIM5α mutations and predicted affect on protein function
From: Interpreting missense mutations in Human TRIM5alpha by computational methods
nsSNP | PolyPhen | SIFT† | A-GVGD | B62PW | Prediction‡ |
|---|---|---|---|---|---|
H43Y | BENIGN | TOLERATED | NEUTRAL | DELETERIOUS | Likely Tolerated (Pi = 0.50) |
C58Y | PROBABLY DAMAGING | DELETERIOUS | DELETERIOUS | DELETERIOUS | Deleterious (Pi = 1.00) |
V77A | BENIGN | TOLERATED | NEUTRAL | TOLERATED | Tolerated (Pi = 1.00) |
D93V | BENIGN | DELETERIOUS | NEUTRAL | DELETERIOUS | Unknown (Pi = 0.33) |
G110E | BENIGN | TOLERATED | NEUTRAL | TOLERATED | Tolerated (Pi = 1.00) |
V112F | POSSIBLY DAMAGING | DELETERIOUS | NEUTRAL | TOLERATED | Unknown (Pi = 0.33) |
R119W | PROBABLY DAMAGING | DELETERIOUS | DELETERIOUS | DELETERIOUS | Deleterious (Pi = 1.00) |
R119Q | BENIGN | DELETERIOUS | POSSIBLY DAMAGING | DELETERIOUS | Likely Deleterious (Pi = 0.50) |
R136Q | BENIGN | TOLERATED | NEUTRAL | TOLERATED | Tolerated (Pi = 1.00) |
V140L | BENIGN | TOLERATED | NEUTRAL | TOLERATED | Tolerated (Pi = 1.00) |
Q143R | POSSIBLY DAMAGING | DELETERIOUS | POSSIBLY DAMAGING | DELETERIOUS | Deleterious (Pi = 1.00) |
R238W | PROBABLY DAMAGING | DELETERIOUS | POSSIBLY DAMAGING | DELETERIOUS | Deleterious (Pi = 1.00) |
G249D | BENIGN | TOLERATED | NEUTRAL | DELETERIOUS | Likely Tolerated (Pi = 0.50) |
P323R | BENIGN | TOLERATED | NEUTRAL | TOLERATED | Tolerated (Pi = 1.00) |
K324N | BENIGN | TOLERATED | NEUTRAL | TOLERATED | Tolerated (Pi = 1.00) |
I328M | BENIGN | TOLERATED | NEUTRAL | TOLERATED | Tolerated (Pi = 1.00) |
G330Q | BENIGN | TOLERATED | NEUTRAL | TOLERATED | Tolerated (Pi = 1.00) |
R332P | BENIGN | TOLERATED | NEUTRAL | TOLERATED | Tolerated (Pi = 1.00) |
I348V | BENIGN | TOLERATED | NEUTRAL | DELETERIOUS | Likely Tolerated (Pi = 0.50) |
T369S | BENIGN | TOLERATED | NEUTRAL | TOLERATED | Tolerated (Pi = 1.00) |
H419Y | BENIGN | TOLERATED | NEUTRAL | TOLERATED | Tolerated (Pi = 1.00) |
V423F | BENIGN | DELETERIOUS | NEUTRAL | TOLERATED | Likely Tolerated (Pi = 0.50) |
V438G | PROBABLY DAMAGING | DELETERIOUS | DELETERIOUS | DELETERIOUS | Deleterious (Pi = 1.00) |
Y444C | BENIGN | DELETERIOUS | NEUTRAL | DELETERIOUS | Unknown (Pi = 0.33) |
A446S | POSSIBLY DAMAGING | DELETERIOUS | NEUTRAL | DELETERIOUS | Likely Deleterious (Pi = 0.50) |
I461L | BENIGN | TOLERATED | NEUTRAL | DELETERIOUS | Likely Tolerated (Pi = 0.50) |
S470P | BENIGN | TOLERATED | NEUTRAL | TOLERATED | Tolerated (Pi = 1.00) |
P479L | PROBABLY DAMAGING | DELETERIOUS | NEUTRAL | DELETERIOUS | Likely Deleterious (Pi = 0.50) |