Cultured hippocampal mocha neurons show higher input resistance. A) The passive membrane current-voltage relationship was examined in control and mocha neurons in primary hippocampal culture. In current clamp, positive and negative current injections were made and the membrane potential deflections were measured. The holding potential before current was injected was -60 mV. The graphs result from recordings in control (n = 11) and mocha neurons (n = 13). B) The neuronal input resistances were calculated from the slope of the linear part of the current-voltage curves shown in A). Mocha neurons had higher input resistances, indicating a smaller membrane conductance compared with controls. *: P < 0.05 unpaired t-test. Values are expressed as mean ± SEM.