Mocha synapses depress faster and to a greater extent. A) Autaptic EPSCs were evoked at 50 Hz in control and mocha mice. B) Normalized EPSC amplitude as a function of the EPSC number in the train. It is seen that the mocha (n = 9) synapses depress more than control (n = 7) (*: P < 0.05). Un-paired t-tests were used to statistically compare relative EPSC amplitude from control and mocha neurons, and values are expressed as mean ± SEM.