Figure 5

A proposed molecular mechanism of resveratrol protection against antibody-induced apoptosis in retinal cells. Antibodies enter the cell through endocytosis and induce an increase in intracellular calcium levels, which in turn trigger the mitochondria-mediated increase in caspase 3 activity and apoptotic death of retinal cells. Resveratrol blocked the intracellular calcium level and blocked the entry of Bax from cytoplasm to mitochondria, which subsequently short-circuited the caspase-3 activation and the cell from death. This figure has been modified from a previously published figure in [9].