TY - JOUR AU - Santamaria, Raül AU - Vilageliu, Lluïsa AU - Grinberg, Daniel PY - 2008 DA - 2008/12/29 TI - SR proteins and the nonsense-mediated decay mechanism are involved in human GLB1 gene alternative splicing JO - BMC Research Notes SP - 137 VL - 1 IS - 1 AB - The human GLB1 gene is known to give rise to two alternatively spliced mRNAs, which encode two different proteins: lysosomal β-galactosidase (β-gal) and elastin-binding protein (EBP). The β-gal transcript includes the 16 exons of the GLB1 gene. In the EBP transcript, exons 3, 4 and 6 are skipped, while exon 5 has a different reading frame. However, little is known on how this alternative splicing is regulated. SN - 1756-0500 UR - https://doi.org/10.1186/1756-0500-1-137 DO - 10.1186/1756-0500-1-137 ID - Santamaria2008 ER -