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Table 3 False positive rates for n-locus permutation distributions.

From: The effect of alternative permutation testing strategies on the performance of multifactor dimensionality reduction

Epistasis Model

N-Locus Permutation Distribution False Positive Rate (%)

Number of Functional Loci

Minor Allele Frequency

Heritability

1 Locus

2 Locus

3 Locus

4 Locus

5 Locus

2

0.2

3%

4

0

100

100

100

2

0.2

2%

2

0

84

76

62

2

0.2

1.5%

3

0

89

78

57

2

0.2

1%

3

1

50

55

33

2

0.2

0.5%

3

1

17

5

6

2

0.4

3%

4

0

95

89

76

2

0.4

2%

7

0

96

93

69

2

0.4

1.5%

7

0

82

57

45

2

0.4

1%

4

1

31

24

19

2

0.4

0.5%

6

3

6

13

8

3

0.2

3%

3

5

0

100

100

3

0.2

2%

2

36

0

100

94

3

0.2

1.5%

2

65

33

67

48

3

0.2

1%

4

40

22

22

22

3

0.2

0.5%

2

1

1

3

3

3

0.4

3%

6

10

0

100

93

3

0.4

2%

5

46

2

57

46

3

0.4

1.5%

3

43

4

61

26

3

0.4

1%

11

12

13

17

4

3

0.4

0.5%

5

10

5

14

6

4

0.2

3%

9

46

85

0

95

4

0.2

2%

4

31

64

4

90

4

0.2

1.5%

1

18

26

11

20

4

0.2

1%

6

5

6

8

18

4

0.2

0.5%

6

9

8

23

11

4

0.4

3%

6

16

63

7

77

4

0.4

2%

0

7

24

3

23

4

0.4

1.5%

4

5

15

3

5

4

0.4

1%

1

14

7

4

12

4

0.4

0.5%

2

11

9

9

3

5

0.2

3%

4

21

51

64

21

5

0.2

2%

1

10

27

64

23

5

0.2

1.5%

1

1

6

6

9

5

0.2

1%

7

14

20

18

13

5

0.2

0.5%

3

2

3

3

5

5

0.4

3%

7

5

11

16

6

5

0.4

2%

1

6

6

12

7

5

0.4

1.5%

7

3

7

8

5

5

0.4

1%

0

2

10

10

6

5

0.4

0.5%

10

6

3

4

6