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Table 4 Power (with or without additional loci) for n-locus permutation distributions.

From: The effect of alternative permutation testing strategies on the performance of multifactor dimensionality reduction

Epistasis Model

N-Locus Permutation Distribution Power (%)

Number of Functional Loci

Minor Allele Frequency

Heritability

1 Locus

2 Locus

3 Locus

4 Locus

5 Locus

2

0.2

3%

0

100

100

100

100

2

0.2

2%

0

100

95

92

89

2

0.2

1.5%

0

91

97

92

89

2

0.2

1%

0

55

80

85

74

2

0.2

0.5%

0

18

45

35

41

2

0.4

3%

0

100

97

93

86

2

0.4

2%

0

100

100

100

92

2

0.4

1.5%

0

100

100

92

80

2

0.4

1%

0

67

73

64

51

2

0.4

0.5%

0

12

40

30

28

3

0.2

3%

0

0

100

100

100

3

0.2

2%

0

0

100

100

100

3

0.2

1.5%

0

0

46

58

55

3

0.2

1%

0

0

2

24

39

3

0.2

0.5%

0

0

1

16

20

3

0.4

3%

0

0

100

100

100

3

0.4

2%

0

0

70

86

67

3

0.4

1.5%

0

0

65

65

39

3

0.4

1%

0

0

10

32

15

3

0.4

0.5%

0

0

2

12

8

4

0.2

3%

0

0

0

100

10

4

0.2

2%

0

0

0

91

10

4

0.2

1.5%

0

0

0

15

4

4

0.2

1%

0

0

0

9

4

4

0.2

0.5%

0

0

0

1

4

4

0.4

3%

0

0

0

82

11

4

0.4

2%

0

0

0

29

6

4

0.4

1.5%

0

0

0

12

4

4

0.4

1%

0

0

0

3

1

4

0.4

0.5%

0

0

0

1

0

5

0.2

3%

0

0

0

0

67

5

0.2

2%

0

0

0

0

49

5

0.2

1.5%

0

0

0

0

0

5

0.2

1%

0

0

0

0

22

5

0.2

0.5%

0

0

0

0

0

5

0.4

3%

0

0

0

0

18

5

0.4

2%

0

0

0

0

2

5

0.4

1.5%

0

0

0

0

1

5

0.4

1%

0

0

0

0

1

5

0.4

0.5%

0

0

0

0

1