Figure 1

The effect of luteolin on the intraerythrocytic growth of P. falciparum. Giemsa-stained smears were prepared at 0, 19, 26 and 48 h after the addition of luteolin (20 μM) dissolved in DMSO or an equal volume of DMSO (control; 0.025% DMSO) to 7G8-infected erythrocytes (1% parasitemia, 2% hematocrit). While control parasites developed into mature trophozoites (26 h) that subsequently gave rise to daughter parasites (48 h), the growth of luteolin-treated parasites was arrested at the young trophozoite stage. Luteolin-treated parasites did not give rise to daughter parasites, resulting in a reduced parasitemia compared to the control at the 48 h time point.