Splice site strength scores for wild-type ASMD exons vs. "all" human exons. These density curves (smooth-line histograms) represent the relative strength of splice sites as determined by the consensus value (CV) method. Donor and acceptor sites are considered separately. The vertical dashed lines indicate the median values. The sample of 193,995 human splice sites was obtained from the Exon-Intron Database's dEID file, version hs35p1, and was confined to the purged sample of 11,316 non-redundant human genes referred to in the Methods section.