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Table 3 Data in patients with fibrosis stage ≥ vs. < 3

From: Hepatic steatosis in patients with HIV-Hepatitis C Virus coinfection: is it associated with antiretroviral therapy and more advanced hepatic fibrosis?

 

Fibrosis stage ≥ 3

n = 27

Fibrosis stage < 3

n = 33

p value

Age at biopsy (yrs)

40.6 ± 8.7

38.3 ± 7.8

ns

Age exposed to HCV (yrs)

20.3 ± 11.0

24.4 ± 7.2

ns

Age at HIV diagnosis (yrs)

33.6 ± 9.6

33.1 ± 6.7

ns

HIV diagnosed in or after 1996

11 (41%)

23 (70%)

0.023

White

8 (30%)

15 (45%)

ns

Alcohol

6 (22%)

12 (36%)

ns

Diabetes Mellitus

1 (4%)

2 (6%)

ns

Weight

70.7 ± 10.0

73.5 ± 10.2

ns

Weight ≥ 75 Kg

11 (41%)

13 (39%)

 

Cholestrol

4.5 ± 1.3

4.0 ± 1.0

ns

Triglycerides (TG)

2.1 ± 1.8

1.8 ± 1.5

ns

Cholestrol/TG ratio

5.0 ± 2.2

3.8 ± 1.3

0.02

Platelet count (/mm3)

163 ± 65.5

228 ± 66.8

0.001

Therapy received

   

None

5 (18%)

12 (36%)

Ns

NRTI

4 (15%)

6 (18%)

Ns

Duration

11.2 ± 8.4

29.3 ± 17.1

0.16

Only HAART

11 (41%)

11 (33%)

Ns

Duration

29.5 ± 26.5

30.4 ± 27.9

Ns

Sequential

7 (26%)

4 (12%)

Ns

Duration

105 ± 23.3

77.5 ± 47.3

0.39

Steatosis

18 (67%)

17 (51%)

Ns

Steatosis grade

1.0 ± 0.9

0.5 ± 0.5

0.028

Necroinflammatory grade

4.4 ± 1.9

3.1 ± 1.3

0.007

CD4 count (/mm3)

370 (130–1100)

510 (100–1200)

0.06

HIV VL (copies/ml)

UD (UD-210955)

28.5 (UD-59540)

Ns

  1. UD: undetectable