Table 3 Common response genes to both A549 cells and THP-1 derived macrophages at 0.5 h and 1 h incubation time periods
From: Streptococcus pneumoniaeearly response genes to human lung epithelial cells
Function/gene name | Protein | TIGR4 genome acc. No. | A549a | THP-1b | ||
|---|---|---|---|---|---|---|
0.5 h | 1 h | 0.5 h | 1 h | |||
Cell envelope | ||||||
cbpI c | choline binding protein I | SP0069 | 2.8 | 8.4 | ||
bgaA | beta-galactosidase | SP0648 | 17.0 | 3.4 | 26.9 | |
nanA c | neuraminidase A, authentic frameshift | SP1693 | 16.5 | 3.9 | 47.1 | |
Energy metabolism | ||||||
agaS | sugar isomerase domain protein AgaS | SP0065 | 5.6 | 10.3 | ||
glgA | glycogen synthase | SP1124 | 3.8 | 5.4 | ||
acetoin dehydrogenase complex, E2 component, dihydrolipoamide acetyltransferase, putative | SP1162 | 2.7 | 4.9 | 6.0 | ||
scrB | sucrose-6-phosphate hydrolase | SP1724 | 3.0 | 4.4 | 2.4 | 4.7 |
galT | galactose-1-phosphate uridylyltransferase | SP1852 | 2.7 | 2.6 | 4.4 | |
galK | galactokinase | SP1853 | 2.3 | 2.3 | 2.8 | |
recP | transketolase | SP2030 | -3.6 | -2.0 | -2.5 | |
gplK | glycerol kinase | SP2186 | 3.0 | 4.1 | ||
Hypothetical proteins | ||||||
hypothetical protein | SP0052 | -3.5 | -5.6 | -2.6 | -3.5 | |
hypothetical protein | SP0067 | 2.4 | 2.1 | 4.1 | ||
conserved hypothetical protein | SP0159 | -2.3 | -2.0 | |||
conserved hypothetical protein | SP0742 | -2.9 | -6.5 | -3.2 | ||
conserved hypothetical protein | SP1003 | 2.1 | 2.1 | 3.4 | ||
hypothetical protein | SP1059 | 4.4 | 56.3 | 16.0 | ||
conserved hypothetical protein | SP1174 | 2.4 | 2.7 | 4.4 | ||
hypothetical protein | SP1198 | 2.7 | 2.6 | 2.8 | ||
hypothetical protein | SP1199 | 2.9 | 2.0 | 2.2 | ||
hypothetical protein | SP1677 | 10.3 | 14.6 | |||
hypothetical protein | SP1678 | 2.9 | 6.1 | 6.9 | ||
hypothetical protein | SP1679 | 4.6 | 9.6 | 6.6 | ||
conserved hypothetical protein | SP1680 | 5.3 | 11.5 | 2.0 | 14.6 | |
Others | ||||||
lactose phosphotransferase system repressor, degenerate | SP0169 | 2.2 | 15.4 | 6.0 | ||
acpP | acyl carrier protein | SP0418 | -2.0 | -2.3 | ||
fabF | 3-oxoacyl-(acyl-carrier-protein) synthase II | SP0422 | -2.4 | -5.1 | ||
bta | bacterocin transport accessory protein | SP1499 | -2.7 | -2.4 | -4.2 | -2.2 |
Protein synthesis | ||||||
rpsD | ribosomal protein S4 | SP0085 | 2.7 | 2.4 | ||
rpsJ | ribosomal protein S10 | SP0208 | 4.1 | 2.9 | ||
rpsC | ribosomal protein S3 | SP0215 | 2.0 | 2.2 | ||
infC | translation initiation factor IF-3 | SP0959 | 2.5 | 2.2 | 2.3 | |
rpmI | ribosomal protein L35 | SP0960 | 3.9 | 2.2 | ||
rpsF | ribosomal protein S6 | SP1541 | 2.9 | 3.0 | 2.2 | |
yfiA | ribosomal subunit interface protein | SP2206 | -3.9 | -2.6 | -2.5 | |
Purine and pyrimidine ribonucleotide biosynthesis | ||||||
purC c | phosphoribosylaminoimidazole-succinocarboxamide synthase | SP0044 | -5.1 | -4.7 | -2.4 | -7.8 |
purH | phosphoribosylaminoimidazolecarboxamide formyltransferase-IMP cyclohydrolase | SP0050 | -15.3 | -4.1 | -4.3 | -5.5 |
purE c | phosphoribosylaminoimidazole carboxylase, catalytic subunit | SP0053 | -6.4 | -8.5 | -4.2 | |
carB | carbamoyl-phosphate synthase, large subunit | SP1275 | -4.2 | -2.6 | ||
pyrR | pyrimidine operon regulatory protein | SP1278 | -2.1 | -7.8 | -2.3 | -4.4 |
Transport | ||||||
PTS system, IIA component | SP0064 | 2.2 | 3.4 | 6.5 | ||
PTS system, mannose-specific IID component | SP0282 | -3.7 | -2.4 | |||
xanthine-uracil permease family protein | SP0287 | -8.4 | -5.3 | -2.3 | ||
PTS system, IIC component, putative | SP0647 | 4.3 | 3.5 | 8.2 | ||
ABC transporter, permease protein | SP1688 | 5.3 | 2.4 | 13.6 | ||
ABC transporter, permease protein | SP1689 | 2.8 | 3.7 | 18.9 | ||
ABC transporter, substrate-binding protein | SP1690 | 2.1 | 3.9 | 21.6 | ||
msmE | sugar ABC transporter, sugar-binding protein | SP1897 | 2.1 | 4.1 | ||
malD | maltodextrin ABC transporter, permease protein | SP2110 | 2.6 | 2.1 | 6.4 | |
Unknown function | ||||||
vanZ protein, putative | SP0049 | -2.9 | -3.4 | -4.9 | ||
ACT domain protein | SP0238 | -2.1 | -3.4 | -2.3 | ||
HIT family protein | SP0521 | -2.4 | -2.1 | |||
flavoprotein | SP1231 | -2.0 | -2.3 | |||