Figure 3

Computation of informativity weight. Empirically, this sigmoid scale is obtained by computing values between -5 and +5 with the arctangent function (corresponding to -1.37 to +1.37 transformed informativity scores). For each experimental design, we re-assign the different informativity values to a -5 to +5 scale (see Figure 3). Let X = {X₀, X₁, ..., X_n} denoting the informativity status value, with n denoting the number of tested animals for one experimental design. Each informativity value is determined as X_i = X_i-1 + 10/n, with X₀ = -5 to fit a scale from -5 to +5. The informativity score values are then expressed from -1.37 to +1.37 (corresponding to -5 and +5 arctangent values respectively). The scores obtained are finally adjusted to a 0 to 2.74 range in order to get only positive score values. vertical axis represents the informativity weight, horizontal axis the informativity values.