The synergy factor: a statistic to measure interactions in complex diseases

BMC Research Notes

Table 2 Data for an SF meta-analysis of the interaction between BACE1 rs638405 GG and APOE4

Study	APOE4-positive, BACE1GG		APOE4-positive, BACE1C+		APOE4-negative, BACE1GG		APOE4-negative, BACE1C+
	Controls	Cases	Controls	Cases	Controls	Cases	Controls	Cases
Nowotny et al 2001 [13]	19	60	48	74	80	38	125	80
Gold et al 2003 [15]	3	14	16	16	41	16	90	46
Clarimon et al 2003 [14]	4	40	10	40	21	18	52	38
Kirschling et al 2003 [16]	22	48	40	62	63	22	112	50

APOE4 = the ε4 allele of apolipoprotein E; BACE1 = the β-site APP-cleaving enzyme; GG and C+ refer to BACE1 exon 5 C/G (rs638405) genotypes; APOE4-positive and BACE1 C+ pool homozygotes and heterozygotes of the respective alleles

ISSN: 1756-0500