Table 1 The statistics of experimental PTM sites and putative PTM sites in this study.
From: A comprehensive resource for integrating and displaying protein post-translational modifications
PTM types | Modified residues | No. of experimental sites | No. of putative sites from UniProtKB/Swiss-Prot | No. of HMM-predicted sites in dbPTM |
|---|---|---|---|---|
Phosphorylation | Serine, threonine, tyrosine, and histidine | 31,363 | 36,080 | 1,815,472 |
N-linked Glycosylation | Asparagine and lysine | 3,264 | 77,571 | 179,955 |
O-linked Glycosylation | Lysine, praline, serine, threonine, and tyrosine | 1,896 | 2,558 | 386,545 |
C-linked Glycosylation | Tryptophan | 53 | 52 | 4,015 |
Acetylation | N-terminal of some residues and side chain of lysine or cysteine | 2,080 | 5,143 | 1,206 |
Amidation | Generally at the C-terminal of a mature active peptide after oxidative cleavage of last glycine | 2,150 | 1,117 | 24,352 |
Hydroxylation | Generally of asparagine, aspartate, proline or lysine | 1,033 | 1,074 | 9,743 |
Methylation | Generally of N-terminal phenylalanine, side chain of lysine, arginine, histidine, asparagine or glutamate, and C-terminal cysteine | 746 | 2,846 | 18,716 |
Pyrrolidone Carboxylic Acid | N-terminal glutamine which has formed an internal cyclic lactam. | 598 | 584 | 12,322 |
Gamma-Carboxyglutamic Acid | Glutamate | 371 | 361 | 1,924 |
Farnesylation | Cysteine | 61 | 216 | 5,349 |
Myristoylation | Glycine | 108 | 765 | 10,998 |
N-Palmitoylation | Cysteine | 33 | 1,279 | 6,554 |
S-Palmitoylation | Cysteine | 177 | 2,303 | 21,287 |
Geranyl-geranylation | Cysteine | 47 | 819 | 14,317 |
S-diacylglycerol cysteine | Cysteine | 36 | 1,529 | 8,977 |
GPI anchoring | C-terminal asparagine, asparate, and serine | 27 | 681 | - |
Deamidation | Amidated asparagine and glutamine (needs to be followed by a G) | 38 | 26 | 2,022 |
Sulfation | Serine, threonine, and tyrosine | 196 | 626 | 15,654 |
Sumoylation | Lysine | 77 | 259 | 10,342 |
Ubiquitylation | Lysine | 286 | 516 | 8,865 |
ADP-ribosylation | Arginine | 3 | 203 | - |
Formylation | Of the N-terminal methionine | 28 | 35 | - |
Citrullination | Arginine | 27 | 91 | - |
Nitration | Tyrosine | 47 | 5 | 1,432 |
Bromination | Tryptophan | 18 | 3 | - |
FAD | O-8alpha-FAD tyrosine, Pros-8alpha-FAD histidine, S-8alpha-FAD cysteine, and Tele-8alpha-FAD histidine | 12 | 116 | - |
S-nitrosylation | Cysteine | 9 | 93 | - |
Others | Â | 1049 | 2,958 | - |
Total | Â | 45,833 | 139,909 | 2,560,047 |