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Table 1 The statistics of experimental PTM sites and putative PTM sites in this study.

From: A comprehensive resource for integrating and displaying protein post-translational modifications

PTM types Modified residues No. of experimental sites No. of putative sites from UniProtKB/Swiss-Prot No. of HMM-predicted sites in dbPTM
Phosphorylation Serine, threonine, tyrosine, and histidine 31,363 36,080 1,815,472
N-linked Glycosylation Asparagine and lysine 3,264 77,571 179,955
O-linked Glycosylation Lysine, praline, serine, threonine, and tyrosine 1,896 2,558 386,545
C-linked Glycosylation Tryptophan 53 52 4,015
Acetylation N-terminal of some residues and side chain of lysine or cysteine 2,080 5,143 1,206
Amidation Generally at the C-terminal of a mature active peptide after oxidative cleavage of last glycine 2,150 1,117 24,352
Hydroxylation Generally of asparagine, aspartate, proline or lysine 1,033 1,074 9,743
Methylation Generally of N-terminal phenylalanine, side chain of lysine, arginine, histidine, asparagine or glutamate, and C-terminal cysteine 746 2,846 18,716
Pyrrolidone Carboxylic Acid N-terminal glutamine which has formed an internal cyclic lactam. 598 584 12,322
Gamma-Carboxyglutamic Acid Glutamate 371 361 1,924
Farnesylation Cysteine 61 216 5,349
Myristoylation Glycine 108 765 10,998
N-Palmitoylation Cysteine 33 1,279 6,554
S-Palmitoylation Cysteine 177 2,303 21,287
Geranyl-geranylation Cysteine 47 819 14,317
S-diacylglycerol cysteine Cysteine 36 1,529 8,977
GPI anchoring C-terminal asparagine, asparate, and serine 27 681 -
Deamidation Amidated asparagine and glutamine (needs to be followed by a G) 38 26 2,022
Sulfation Serine, threonine, and tyrosine 196 626 15,654
Sumoylation Lysine 77 259 10,342
Ubiquitylation Lysine 286 516 8,865
ADP-ribosylation Arginine 3 203 -
Formylation Of the N-terminal methionine 28 35 -
Citrullination Arginine 27 91 -
Nitration Tyrosine 47 5 1,432
Bromination Tryptophan 18 3 -
FAD O-8alpha-FAD tyrosine, Pros-8alpha-FAD histidine, S-8alpha-FAD cysteine, and Tele-8alpha-FAD histidine 12 116 -
S-nitrosylation Cysteine 9 93 -
Others   1049 2,958 -
Total   45,833 139,909 2,560,047