Table 1 Cell line characteristics
Parental cell line | Sub-line(s) | Origin | Selecting agent | Proposed resistance mechanism |
|---|---|---|---|---|
CCRF-CEM | CEM/VM-1 | Leukaemia | Teniposide | Topo II-associated |
NCI-H69 | H69/AR | SCLC | Doxorubicin | MRP |
RPMI8226/S | 8226/Dox40 | Myeloma | Doxorubicin | Pgp |
8226/LR5 | Melphalan | GSH | ||
U-937 GTB | U-937 Vcr | Lymphoma | Vincristin | Tubulin-associated |
ACHN | - | Renal | Primary resistant |