Figure 1
From: Identification of osteopontin-dependent signaling pathways in a mouse model of human breast cancer
Gene expression profiling. A. Microarray heat map analysis of mouse primary tumors treated by OPN-R3(left); wild type non-treatment (middle) and Mutant OPN-R3 aptamer. The panel shows gene expression fold change compared with the mean normalized value of controls (wild type non-treatment and mutant OPN-R3 aptamer treatment). The intensity of the node color indicates the degree of increase (red) or decrease (blue) gene expression. B, C. Scatter plots showing differentially expressed genes between mutant OPN-R3 aptamer treatment and OPN-R3 aptamer treatment (B) and between wild type non-treatment and mutant OPN-R3 treatment control(C). D. List of the dysregulated genes associated with down regulated and up regulated canonical signal transduction pathways.