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Table 2 The effects of allopeptide pulsed and unpulsed IL-4 DC and IL-10 DC in vivo.

From: Inhibitory effects of rat bone marrow-derived dendritic cells on naïve and alloantigen-specific CD4+ T cells: a comparison between dendritic cells generated with GM-CSF plus IL-4 and dendritic cells generated with GM-CSF plus IL-10

Group Origin of DC Donor of heart allografts Survival time (d) of heart allografts in LEW recipients MST ± SD (d)1) Median (d) n
1 Syngeneic Ctr ---2) LEW > 50(×3) > 50 50 3
2 Syngeneic Ctr + P1 --- LEW > 50(×3) > 50 50 3
3 Allogeneic Ctr I --- WF 7(×4), 8(×2) 7.3 ± 0.5 7.0 6
4 Allogeneic Ctr I + P13) --- WF 5(×4), 6(×2) 5.3 ± 0.5 5.0 6
5 1 × 107 IL-4 DC LEW 4) WF 6, 7(×4) 6.8 ± 0,5 7.0 5
6 1 × 107 IL-4 DC + P1 LEW WF 9(×3), 11 9.5 ± 1.0 9.0 4
7 1 × 107 IL-10 DC LEW WF 7(×7), 8 7.1 ± 0.4 7.0 8
8 1 × 107 IL-10 DC + P1 LEW WF 8, 9(×2), 10(×5) 9.5 ± 0.8 10 8
9 Allogeneic Ctr II --- BN 7(×3) 7.0 7.0 3
10 Allogeneic Ctr II + P1 --- BN 7(×3),8 7.3 ± 0.5 7.0 4
11 1 × 107 IL-4 DC LEW BN 7(×3) 7.0 7.0 3
12 1 × 107 IL-4 DC + P1 LEW BN 7(×2), 8 7.3 ± 0.6 7.0 3
13 1 × 107 IL-10 DC LEW BN 7(×3) 7.0 7.0 3
14 1 × 107 IL-10 DC + P1 LEW BN 7(×3) 7.0 7.0 3
  1. 1) Mean survival time ± standard deviation in days (d).
  2. 2) No DC treatment performed.
  3. 3) Animals were immunised with P1 7 days prior to transplantation.
  4. 4) LEW: Lewis rats, WF: Wistar Furth rats, BN: Brown Norway rats.