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Table 1 Patients and tumour characteristics

From: Analysis of cyclins A, B1, D1 and E in breast cancer in relation to tumour grade and other prognostic factors

Variable

Number of patients (%)

Number of the patients

Grade

53 (aged 40–94, mean 67)

   I

7 (13.2%)

   II

24 (45.3%)

   III

18 (34%)

   in situ II

1 (1.9%)

   in situ III

3 (5.7%)

Axillary nodal status

 

   N0

25 (47.2%)

   N1–3

12 (22.6%)

   N4–9

11 (20.8%)

   >N10

3 (5.7%)

   Unknown (axillary evacuation done 1993 and 1994)

2 (3.8%)

Tumour size

 

   ≤ 2 cm

13 (24.5%)

   > 2 cm

40 (75.5%)

Estrogen receptor status (ER) 1)

 

   Positive

35 (66%)

   Negative

14 (26.4%)

   Positive in DCI

3 (5.7%)

   Negative in DCIS

1 (1.9%)

Progesterone receptor status (PR) 1)

 

   Positive

36 (68%)

   Negative

13 (24.5%)

   Positive in DCIS

3 (5.7%)

   Negative in DCIS

1 (1.9%)

Ki-67 status

 

   <5%

7 (13.2%)

   5–19%

16 (30.2%)

   20–29%

8 (15.1%)

   >20%

22 (41.5%)

Histologic type

 

   Ductal

37 (69.8%)

   Lobular

8 (15.1%)

   Subtypes

4 (7.5%)

   Ductal carcinoma in situ

4 (7.5%)

Her-2 2)

 

   IHC positive (2+ and 3+)

20 (37.7%)

   IHC negative (0 and 1+)

29 (54.7%)

   IHC positive in DCIS

2 (3.8%)

   IHC negative in DCIS

2 (3.8%)

   CISH positive

10 (18.9%)

   CISH positive in DCIS

2 (3.8%)

CK 5/6 3)

 

   Triple-negative (ER-, PR-, Her-2/neu-)

11 (20.8%)

   Basal-like carcinoma (ER-, PR-, Her-2/neu-, CK5/6+)

8 (15.1%)

  1. 1,3) Cut off point used for ER and PR immunohistochemistry is 10% of positively stained tumour cell nuclei and 10% cytoplasmic staining for CK5/6.
  2. 2) All IHC Her 2+ and 3+ cases were retested by CISH. Scoring of HER2/neu immunohistochemistry: Score 0: no staining is observed or cell membrane staining is observed in less than 10% of tumour cells. Score 1+: a faint perceptible membrane staining can be detected in more than 10% of the tumour cells or cells are only stained in part of their membrane. Score 2+: a weak to moderate complete membrane staining is observed in more than 10% of the tumour cells. Score 3+: a strong complete membrane staining is observed in more than 10% of the tumour cells.