Cancer gene network: comparing MAST to hierarchical clustering. Both procedures allow for unassigned (unclustered) genes. (a) Rand index (y-axis) with gene ontology as a function of the percentage of assigned genes (x-axis). Since the blue line (MAST procedure) tends to be higher than the red line (hierarchical clustering), MAST performs better in this application. (b) Hierarchical clustering dendrogram with the pairwise TOM. The first color band underneath the tree shows the results of defining modules as branches of the tree. 'Grey' is reserved for unassigned genes. The second color band depicts the module assignment of the MAST procedure. The third colorband depicts the known gene ontologies. (c) The barplots on the left hand side and on the right hand side show the functional enrichment of modules (x-axis) found by the MAST procedure and by hierarchical clustering, respectively. The height of the barplots equals the proportion of module genes that are known to be apoptosis related (yellow bars), neurogenesis related (blue bars), and DNA replication related (red bars). Both clustering procedures find 3 similar modules.