Comparison of different module detection methods for simulation I with mixed modules. The clustering tree results from average linkage hierarchical clustering with the pairwise topological overlap measure. The first color band underneath the tree colors the branches (modules) that result after cutting off the branches with a fixed height cut-off. When compared to the last color band that corresponds to the true simulated modules, it becomes clear that the method fails at retrieving the fourth (yellow) module irrespective of the height cut-off. The second color band corresponds to the module colors retrieved from PAM clustering with k = 4. It fails to retrieve true membership as one can see by comparing it to the true colors in the last row. Color bands 3 through 5 correspond to the steps of the MAST procedure. The fifth row shows the final result of the MAST procedure. When compared to the last color band that corresponds to the true simulated modules, it becomes clear that the MAST procedure retrieves the true underlying module structure. In particular, it can retrieve the yellow module as well.