Table 2 Predictive factors for tumor response and risk factors associated with ILD (univariate analysis)
Factor | Response proportion (%) | Odds ratio (95% CI) | p-value | Incidence of ILD (%) | Odds ratio (95% CI) | p-value |
|---|---|---|---|---|---|---|
Age | - | 1.01 (0.98–1.03) | 0.644 | 1.00 (0.95–1.04) | 0.823 | |
Sex | ||||||
Male | 8.4 | 1 | - | 2.7 | 1 | - |
Female | 34.3 | 5.68 (3.33–9.69) | <0.001 | 4.2 | 1.60 (0.61–4.21) | 0.344 |
Histological type | ||||||
Non-adenocarcinoma | 6.0 | 1 | - | 3.6 | 1 | - |
Adenocarcinoma | 23.6 | 4.86 (2.27–10.42) | <0.001 | 3.1 | 0.84 (0.31–2.33) | 0.737 |
History of smoking | ||||||
Yes | 10.5 | 1 | - | 3.1 | 1 | - |
No | 33.8 | 4.33 (2.57–7.29) | <0.001 | 4.1 | 1.33 (0.50–3.57) | 0.573 |
ECOG performance status | ||||||
2–4 | 14.4 | 1 | - | 2.6 | 1 | - |
0–1 | 20.3 | 1.51 (0.89–2.59) | 0.129 | 3.6 | 1.39 (0.48–4.00) | 0.549 |
Concurrent interstitial pneumonitis | ||||||
No | 18.9 | 1 | - | 3.2 | 1 | |
Yes | 5.0 | 0.23 (0.03–1.72) | 0.151 | 3.8 | 1.21 (0.15–9.49) | |
Concurrent pulmonary emphysema | ||||||
No | 19.9 | 1 | - | 3.1 | 1 | |
Yes | 7.1 | 0.31 (0.11–0.88) | 0.028 | 3.9 | 1.25 (0.35–4.47) | |
Prior surgery | ||||||
No | 16.0 | 1 | - | 3.6 | 1 | - |
Yes | 22.2 | 1.49 (0.91–2.44) | 0.111 | 2.6 | 0.74 (0.26 -2.12) | 0.571 |
Prior chemotherapy | ||||||
No | 28.6 | 1 | - | 2.6 | 1 | - |
Yes | 15.5 | 0.46 (0.27–0.79) | 0.005 | 3.4 | 1.32 (0.37–4.66) | 0.670 |
Prior thoracic radiotherapy | ||||||
No | 19.3 | 1 | - | 3.9 | 1 | - |
Yes | 16.6 | 0.83 (0.50–1.38) | 0.468 | 2.1 | 0.51 (0.17–1.60) | 0.250 |
Concurrent chemotherapy with agent other than gefitinib | ||||||
No | 17.3 | 1 | - | 3.5 | - | - |
Yes | 28.6 | 1.91 (0.88–4.15) | 0.103 | 0 | - | - |
Thoracic radiotherapy concurrent with or after gefitinib treatment | ||||||
No | 18.8 | 1 | - | 3.1 | 1 | - |
Yes | 12.8 | 0.64 (0.24–1.69) | 0.364 | 4.2 | 1.34 (0.30–6.05) | 0.702 |
Absolute neutrophil count * | - | 0.84 (0.75–0.95) | 0.004 | - | 0.96 (0.81–1.14) | 0.609 |
Aspartate aminotransferase level ** | - | 1.00 (0.99–1.01) | 0.967 | - | 0.99 (0.95–1.03) | 0.635 |
Lactate dehydrogenase level *** | - | 0.82 (0.65–1.03) | 0.085 | - | 0.95 (0.71–1.27) | 0.724 |
Albumin level **** | - | 1.54 (0.97–2.44) | 0.067 | - | 1.65 (0.67–4.07) | 0.278 |