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Table 2 Predictive factors for tumor response and risk factors associated with ILD (univariate analysis)

From: Interstitial lung disease in gefitinib-treated Japanese patients with non-small cell lung cancer – a retrospective analysis: JMTO LC03-02

Factor Response
proportion (%)
Odds
ratio (95% CI)
p-value Incidence of
ILD (%)
Odds ratio
(95% CI)
p-value
Age - 1.01 (0.98–1.03) 0.644   1.00 (0.95–1.04) 0.823
Sex       
   Male 8.4 1 - 2.7 1 -
   Female 34.3 5.68 (3.33–9.69) <0.001 4.2 1.60 (0.61–4.21) 0.344
Histological type       
   Non-adenocarcinoma 6.0 1 - 3.6 1 -
   Adenocarcinoma 23.6 4.86 (2.27–10.42) <0.001 3.1 0.84 (0.31–2.33) 0.737
History of smoking       
   Yes 10.5 1 - 3.1 1 -
   No 33.8 4.33 (2.57–7.29) <0.001 4.1 1.33 (0.50–3.57) 0.573
ECOG performance status       
   2–4 14.4 1 - 2.6 1 -
   0–1 20.3 1.51 (0.89–2.59) 0.129 3.6 1.39 (0.48–4.00) 0.549
Concurrent interstitial pneumonitis       
   No 18.9 1 - 3.2 1  
   Yes 5.0 0.23 (0.03–1.72) 0.151 3.8 1.21 (0.15–9.49)  
Concurrent pulmonary emphysema       
   No 19.9 1 - 3.1 1  
   Yes 7.1 0.31 (0.11–0.88) 0.028 3.9 1.25 (0.35–4.47)  
Prior surgery       
   No 16.0 1 - 3.6 1 -
   Yes 22.2 1.49 (0.91–2.44) 0.111 2.6 0.74 (0.26 -2.12) 0.571
Prior chemotherapy       
   No 28.6 1 - 2.6 1 -
   Yes 15.5 0.46 (0.27–0.79) 0.005 3.4 1.32 (0.37–4.66) 0.670
Prior thoracic radiotherapy       
   No 19.3 1 - 3.9 1 -
   Yes 16.6 0.83 (0.50–1.38) 0.468 2.1 0.51 (0.17–1.60) 0.250
Concurrent chemotherapy with
agent other than gefitinib
      
   No 17.3 1 - 3.5 - -
   Yes 28.6 1.91 (0.88–4.15) 0.103 0 - -
Thoracic radiotherapy concurrent
with or after gefitinib treatment
      
   No 18.8 1 - 3.1 1 -
   Yes 12.8 0.64 (0.24–1.69) 0.364 4.2 1.34 (0.30–6.05) 0.702
Absolute neutrophil count * - 0.84 (0.75–0.95) 0.004 - 0.96 (0.81–1.14) 0.609
Aspartate aminotransferase level ** - 1.00 (0.99–1.01) 0.967 - 0.99 (0.95–1.03) 0.635
Lactate dehydrogenase level *** - 0.82 (0.65–1.03) 0.085 - 0.95 (0.71–1.27) 0.724
Albumin level **** - 1.54 (0.97–2.44) 0.067 - 1.65 (0.67–4.07) 0.278
  1. * per: 1000/μL **: per IU/L ***: per 100 IU/L ****: per g/dL