Multiple sequence alignment of five proteins from Chlamydophila genomes. The C. pneumoniae J138 and C. felis Fe/C-56 proteins displayed are annotated as O-sialoglycoprotein endopeptidase. CGUG analysis reveals counterpart proteins from C. abortus S26/3, C. pneumoniae AR39 and C. caviae GPIC that are annotated currently as "hypothetical proteins." As an example of additional bioinformatic analysis suggested by CGUG results, these counterparts are aligned to determine their identity to O-sialoglycoprotein endopeptidase. Conserved residues are indicated by asterisks. Colons indicate conserved substitutions, based on amino acid physico-chemical properties. Dots indicate semi-conserved substitutions.