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Table 1 Plasma IP-10, MCP-3, MCP-2, IFN-γ, MCP-1 and IL-1RA release in antigen stimulated whole blood culture

From: IP-10, MCP-1, MCP-2, MCP-3, and IL-1RA hold promise as biomarkers for infection with M. tuberculosis in a whole blood based T-cell assay

  Controls (n = 7) TB patients (n = 8) p-value
IP-10    
   Nil 5 (5–57)1 157 (102–301) 0.0047
   Antigen 46 (0–63) 9010 (5542–13785) 0.0011
   Mitogen 3601 (1702–5918) 4835 (2112–7075) 0.7285
MCP-3    
   Nil 737 (320–1202) 3464 (1442–5517) 0.0372
   Antigen 807 (147–1236) 9206 (7221–11296) 0.0012
   Mitogen 2224 (1724–2964) 9393 (4538–13966) 0.0109
MCP-2    
   Nil 24 (17–43) 26 (24–46) 0.4724
   Antigen 33 (24–43) 2208 (914–3781) 0.0012
   Mitogen 4673 (1908–6601) 3379 (474–5592) 0.4875
IFN-γ    
   Nil 8 (7–9) 8 (7–14) 0.4859
   Antigen 8 (6–9) 223 (179–601) 0.0012
   Mitogen 1326 (534–1363) 327 (92–724) 0.0279
MCP-1    
   Nil 6352 (3110–13560) 6120 (4723–15527) 0.8170
   Antigen 7206 (5368–12471) 44991 (25831–56822) 0.0012
   Mitogen 27773 (20500–42559) 46926 (26396–80328) 0.2030
IL-1RA    
   Nil 3371 (1277–7983) 6328 (3035–9415) 0.4875
   Antigen 3986 (2386–6893) 26002 (18226–33934) 0.0054
   Mitogen 54397 (29233–77086) 15966 (12106–27296) 0.0091
  1. 1 Median (Inter Quartile Range)