Table 1 Plasma IP-10, MCP-3, MCP-2, IFN-γ, MCP-1 and IL-1RA release in antigen stimulated whole blood culture
Controls (n = 7) | TB patients (n = 8) | p-value | |
|---|---|---|---|
IP-10 | |||
Nil | 5 (5–57)1 | 157 (102–301) | 0.0047 |
Antigen | 46 (0–63) | 9010 (5542–13785) | 0.0011 |
Mitogen | 3601 (1702–5918) | 4835 (2112–7075) | 0.7285 |
MCP-3 | |||
Nil | 737 (320–1202) | 3464 (1442–5517) | 0.0372 |
Antigen | 807 (147–1236) | 9206 (7221–11296) | 0.0012 |
Mitogen | 2224 (1724–2964) | 9393 (4538–13966) | 0.0109 |
MCP-2 | |||
Nil | 24 (17–43) | 26 (24–46) | 0.4724 |
Antigen | 33 (24–43) | 2208 (914–3781) | 0.0012 |
Mitogen | 4673 (1908–6601) | 3379 (474–5592) | 0.4875 |
IFN-γ | |||
Nil | 8 (7–9) | 8 (7–14) | 0.4859 |
Antigen | 8 (6–9) | 223 (179–601) | 0.0012 |
Mitogen | 1326 (534–1363) | 327 (92–724) | 0.0279 |
MCP-1 | |||
Nil | 6352 (3110–13560) | 6120 (4723–15527) | 0.8170 |
Antigen | 7206 (5368–12471) | 44991 (25831–56822) | 0.0012 |
Mitogen | 27773 (20500–42559) | 46926 (26396–80328) | 0.2030 |
IL-1RA | |||
Nil | 3371 (1277–7983) | 6328 (3035–9415) | 0.4875 |
Antigen | 3986 (2386–6893) | 26002 (18226–33934) | 0.0054 |
Mitogen | 54397 (29233–77086) | 15966 (12106–27296) | 0.0091 |