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Table 1 Plasma IP-10, MCP-3, MCP-2, IFN-γ, MCP-1 and IL-1RA release in antigen stimulated whole blood culture

From: IP-10, MCP-1, MCP-2, MCP-3, and IL-1RA hold promise as biomarkers for infection with M. tuberculosis in a whole blood based T-cell assay

 

Controls (n = 7)

TB patients (n = 8)

p-value

IP-10

   

   Nil

5 (5–57)1

157 (102–301)

0.0047

   Antigen

46 (0–63)

9010 (5542–13785)

0.0011

   Mitogen

3601 (1702–5918)

4835 (2112–7075)

0.7285

MCP-3

   

   Nil

737 (320–1202)

3464 (1442–5517)

0.0372

   Antigen

807 (147–1236)

9206 (7221–11296)

0.0012

   Mitogen

2224 (1724–2964)

9393 (4538–13966)

0.0109

MCP-2

   

   Nil

24 (17–43)

26 (24–46)

0.4724

   Antigen

33 (24–43)

2208 (914–3781)

0.0012

   Mitogen

4673 (1908–6601)

3379 (474–5592)

0.4875

IFN-γ

   

   Nil

8 (7–9)

8 (7–14)

0.4859

   Antigen

8 (6–9)

223 (179–601)

0.0012

   Mitogen

1326 (534–1363)

327 (92–724)

0.0279

MCP-1

   

   Nil

6352 (3110–13560)

6120 (4723–15527)

0.8170

   Antigen

7206 (5368–12471)

44991 (25831–56822)

0.0012

   Mitogen

27773 (20500–42559)

46926 (26396–80328)

0.2030

IL-1RA

   

   Nil

3371 (1277–7983)

6328 (3035–9415)

0.4875

   Antigen

3986 (2386–6893)

26002 (18226–33934)

0.0054

   Mitogen

54397 (29233–77086)

15966 (12106–27296)

0.0091

  1. 1 Median (Inter Quartile Range)