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Table 1 Frequency of fecal shedding at different time point as detected by IS900 PCR and isolation and rate of reduction between pre-intervention sampling and last control.

From: Significant reduction in bacterial shedding and improvement in milk production in dairy farms after the use of a new inactivated paratuberculosis vaccine in a field trial

IS900-PCR AI0 PI1 PI2 PI4     
Herd n % n % n % n % Herd shedding reduction P Strategy reduction p
T&C HER 196 7.65 195 4.62 182 2.20   - 71.1% 0.0126 60.4% 0.0039
  URI 144 9.72 176 9.09 143 4.90   - 49.6% 0.0890   
  AGE 76 17.11 76 2.63 79 2.53   - 85.2% 0.0019   
VAC END 0 - 0 - 64 3.13 71 0.0 100.0%* 0.2229   
  SAG 46 32.56 48 0.00 34 5.88   - 81.9% 0.0036 85.8% <0.0001
  SAL 63 15.87 60 20.00 65 1.54   - 90.3% 0.0037   
MAP isolation AI0 PI1 PI2 PI4     
Herd n % n % n %    Herd shedding reduction P Strategy reduction P
T&C HER 193 6.74 195 3.59 182 1.65    75.4% 0.0127 45.5% 0.0760
  URI 143 4.20 176 4.55 143 4.90    -16.7% 0.7140   
  AGE 76 2.63 76 2.63 79 0.00 - - 100.0% 0.2388   
VAC END 88 7.95 50 10.00 64 3.13 71 0.0 100.0%* 0.0142   
  SAG 46 0 48 0.00 38 5.26    - 0.1981 68.2% 0.0243
  SAL 63 7.94 60 1.67 65 0.00    100.0% 0.0266   
  1. T&C: Testing and culling; VAC: Vaccination; HER, URI, AGE, END, SAG, SAL: Herd codes; AI0: Ante-intervention sampling; PI1: First post-intervention sampling; PI2: Second post-intervention sampling (includes 48 months control for farm END); PI4: Fourth post-intervention sampling (corresponds to 60 months post-intervention only for END). Reduction is calculated as the quotient of the difference in proportions to the initial proportion. * Herd reduction calculated at the last control for END. p: Fisher exact test probability of the difference being due to chance.