Figure 4

EpoR mRNA expression in the peripheral normal (A-C) and diabetic (D-F) retina. A, Phase contrast micrograph of the peripheral normal human retina. B, Anti-sense RNA probes for EpoR in normal retina demonstrates expression in the few retinal ganglion cells present in the peripheral retina. C, Control sense RNA probes for EpoR in normal retina. D, Phase contrast micrograph of a diabetic human retina shows loss of cytoarchitecture. E, Anti-sense RNA probes for EpoR shows intense signal in the peripheral retina. F, Control sense RNA probes for EpoR in diabetic retina. Abbreviations: RGC, retinal ganglion cell layer; INL, inner nuclear layer; ONL outer nuclear layer; RPE, retinal pigment epithelium layer; PS, photoreceptor segments.