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Table 1 Counts (n), frequencies (%) and association statistics for genotypes and minor-alleles (FasR-1377G/A, FasR-670A/G, FasL-844T/C).

From: Fas and FasL gene polymorphisms are not associated with cervical cancer but differ among Black and Mixed-ancestry South Africans

  Black Mixed-ancestry Genotype-cervical cancer association, adjusted for ethnicity Genotype-ethnic association, in controls only
  Cases Controls Cases Controls     
Genotypes n (%) n (%) n (%) n (%) P-value OR (95% CI) P-value OR (95% CI)
FASR-1377 G→A
GG 74 (77) 75 (83) 186 (64) 196 (66) - 1 - 1
AG 21 (22) 14 (16) 87 (30) 86 (29) 0.428 1.14 (0.83-1.58) 0.007 0.43 (0.22-0.77)
AA 1 (1) 1 (1) 17 (6) 13 (4) 0.391 1.37 (0.67-2.87) 0.130 0.20 (0.01-1.04)
A allele 23 (12) 16 (9) 121 (21) 112 (19) 0.275 1.15 (0.89-1.49) 0.003 0.43 (0.24-0.72)
FASR-670 A→G
GG 67 (65) 54 (55) 147 (44) 136 (42) - 1 - 1
AG 35 (34) 43 (43) 132 (40) 146 (45) 0.099 0.79 (0.59-1.05) 0.207 0.74 (0.46-1.18)
AA 1 (1) 2 (2) 53 (16) 39 (12) 0.492 1.17 (0.74-1.87) 0.006 0.13 (0.02-0.44)
A allele 37 (18) 47 (24) 238 (36) 224 (35) 0.778 0.97 (0.79-1.19) 0.003 0.57 (0.39-0.82)
FASL -844 T→C
TT 70 (68) 74 (74) 143 (44) 139 (44) - 1 - 1
CT 31 (30) 23 (23) 144 (44) 136 (43) 0.515 1.1 (0.82-1.48) < 0.001 0.32 (0.18-0.53)
CC 2 (2) 3 (3) 40 (12) 40 (13) 0.929 0.98 (0.61-1.57) 0.001 0.14 (0.03-0.41)
C allele 35 (17) 29 (14) 224 (34) 216 (34) 0.797 1.03 (0.83-1.27) < 0.001 0.34 (0.22-0.51)
  1. P-values and OR (95% confidence intervals) are for test of genotype or additive allelic association with cervix cancer risk, adjusted for ethnicity, and for genotype/additive association with ethnicity in controls. For genotypes, P-values next to genotype names are for joint model, others are for ORs of specific genotype compared to reference genotype, indicated with OR = 1. ORs for alleles are the odds for an additional copy of that allele. ORs for genotype-ethnicity association (in controls only) are odds of genotype/allele in black compared to odds of genotype/allele in individuals of mixed-ancestry.
  2. Cases = Women with cancer of the cervix, Controls = Women without cancer of the cervix.