Table 1 Counts (n), frequencies (%) and association statistics for genotypes and minor-alleles (FasR-1377G/A, FasR-670A/G, FasL-844T/C).
| Â | Black | Mixed-ancestry | Genotype-cervical cancer association, adjusted for ethnicity | Genotype-ethnic association, in controls only | ||||
|---|---|---|---|---|---|---|---|---|
| Â | Cases | Controls | Cases | Controls | Â | Â | Â | Â |
Genotypes | n (%) | n (%) | n (%) | n (%) | P-value | OR (95% CI) | P-value | OR (95% CI) |
FASR-1377 G→A | ||||||||
GG | 74 (77) | 75 (83) | 186 (64) | 196 (66) | - | 1 | - | 1 |
AG | 21 (22) | 14 (16) | 87 (30) | 86 (29) | 0.428 | 1.14 (0.83-1.58) | 0.007 | 0.43 (0.22-0.77) |
AA | 1 (1) | 1 (1) | 17 (6) | 13 (4) | 0.391 | 1.37 (0.67-2.87) | 0.130 | 0.20 (0.01-1.04) |
A allele | 23 (12) | 16 (9) | 121 (21) | 112 (19) | 0.275 | 1.15 (0.89-1.49) | 0.003 | 0.43 (0.24-0.72) |
FASR-670 A→G | ||||||||
GG | 67 (65) | 54 (55) | 147 (44) | 136 (42) | - | 1 | - | 1 |
AG | 35 (34) | 43 (43) | 132 (40) | 146 (45) | 0.099 | 0.79 (0.59-1.05) | 0.207 | 0.74 (0.46-1.18) |
AA | 1 (1) | 2 (2) | 53 (16) | 39 (12) | 0.492 | 1.17 (0.74-1.87) | 0.006 | 0.13 (0.02-0.44) |
A allele | 37 (18) | 47 (24) | 238 (36) | 224 (35) | 0.778 | 0.97 (0.79-1.19) | 0.003 | 0.57 (0.39-0.82) |
FASL -844 T→C | ||||||||
TT | 70 (68) | 74 (74) | 143 (44) | 139 (44) | - | 1 | - | 1 |
CT | 31 (30) | 23 (23) | 144 (44) | 136 (43) | 0.515 | 1.1 (0.82-1.48) | < 0.001 | 0.32 (0.18-0.53) |
CC | 2 (2) | 3 (3) | 40 (12) | 40 (13) | 0.929 | 0.98 (0.61-1.57) | 0.001 | 0.14 (0.03-0.41) |
C allele | 35 (17) | 29 (14) | 224 (34) | 216 (34) | 0.797 | 1.03 (0.83-1.27) | < 0.001 | 0.34 (0.22-0.51) |