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Table 1 Parameter differences between circuits of group 1 and circuits of group 2-3.

From: Inferring Drosophila gap gene regulatory network: pattern analysis of simulated gene expression profiles and stability analysis

parameter differences between circuits of group 1 and group 2-3
θ m 1 m 2 dm p - value
tllcad -0.0171377 -0.02491 -0.00777229 1.04553e - 010
hbhb 0.0217064 0.015097 -0.00660943 1.34364e - 011
gthb 0.0122061 -0.00414659 -0.0163527 0
knihb -0.128935 -0.0747608 0.0541739 5.28773e - 009
KrKr 0.0161343 0.0227917 0.00665739 4.79087e - 007
gtKr -0.0528814 -0.027446 0.0254355 2.71076e - 010
hbgt -0.003434 0.00397726 0.00741126 8.47311e - 011
gtgt 0.0132754 0.0164244 0.00314898 2.4076e - 006
tllgt -0.0155584 -0.0438868 -0.0283284 1.11022e - 015
gttll -0.0252096 -0.00316618 0.0220435 3.74904e - 007
mKr 0.0525071 0.0306038 -0.0219033 6.33614e - 007
mgt 0.0703723 0.0261228 -0.0442495 8.70947e - 009
  1. T-test comparison of circuit parameters belonging to a group with a normal pattern without any defection (group 1) and a solution for which hb has a dip and tll a bump (group 2 and 3).
  2. In groups 2 and 3, Gt represses hb, causing the dip observed at anterior hb. Also, Hb activates gt (contrarily to group 1). Consequently, there should be an increased production of anterior gt and something should locally repress gt to keep it at its normal level. At this position, Tll is the gene that controls gt expression level, and one way to keep it constant would be to increase the repression weight.
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