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Table 4 Region of 17q21 with summed heterozygosity score exceeding 50.

From: Markers typed in genome-wide analysis identify regions showing deviation from Hardy-Weinberg equilibrium

Marker or gene

Position

 

Marker genotype counts

Observed

Expected

Heterozygosity scores for single, two and three marker analysis

Gene description

   

AA

AB

BB

1

2

3

 

LOC339192

40652465

Start

      

hypothetical protein LOC339192

FMNL1

40655075

Start

      

formin-like 1

LOC339192

40675042

End

       

FMNL1

40680468

End

       

C17orf46

40687543

Start

      

chromosome 17 open reading frame 46

C17orf46

40695262

End

       

MAP3K14

40696271

Start

      

mitogen-activated protein kinase kinase kinase 14

MAP3K14

40750197

End

       

rs4792855

40815480

 

405

746

329

0.2

0.3

0.3

 
   

409

738

333

    

rs1230094

40825939

 

751

622

107

0.6

0.7

0.6

 
   

762.1

599.9

118.1

    

rs732589

40826543

 

762

617

101

0.7

0.6

0.5

 
   

774.3

592.4

113.3

    

ARHGAP27

40827058

Start

      

Rho GTPase activating protein 27

rs1230103

40841574

 

753

619

108

0.5

0.5

0.2

 
   

762.8

599.5

117.8

    

rs12947718

40848884

 

977

458

45

0.3

0

0

 
   

982.7

446.5

50.7

    

ARHGAP27

40858780

End

       

LOC201175

40862501

Start

      

hypothetical protein LOC201175

LOC201175

40867570

End

       

PLEKHM1

40869049

Start

      

pleckstrin homology domain containing, family M (with RUN domain) member 1

rs17631303

40872185

 

1036

399

45

-0.2

0

-0.1

 
   

1031.4

408.2

40.4

    

rs3946526

40897439

 

980

455

45

0.3

0.1

49.4

 
   

985.2

444.7

50.2

    

rs2078200

40897617

 

803

573

104

0

80.1

79.7

 
   

802

574.9

103

    

PLEKHM1

40923893

End

       

LOC644354

40934084

Start

      

similar to Apoptosis-related protein 2 (APR-2)

LOC644354

40934428

End

       

LRRC37A4

40939890

Start

      

leucine rich repeat containing 37, member A4 (pseudogene)

LRRC37A4

40948305

End

       

rs2696639

41006823

 

89

1312

79

193.6

193.6

191.3

 
   

375

740

365

    

rs2696640

41007016

 

88

1312

80

193.6

192

192

 
   

374

740

366

    

rs2693363

41007205

 

93

1307

80

190.3

192.6

192.6

 
   

376.5

739.9

363.5

    

rs2693364

41007294

 

87

1314

79

195

195

153.4

 
   

374

740

366

    

rs2693371

41011471

 

87

1314

79

195

153.4

153.4

 
   

374

740

366

    

rs17642476

41012163

 

1298

182

0

0.4

153.4

75.8

 
   

1303.6

170.8

5.6

    

rs2463520

41015138

 

87

1314

79

195

98.8

98.8

 
   

374

740

366

    

LOC644157

41018375

Start

      

similar to dead end homolog 1