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Table 3 Genotype and allele counts for NOD1/CARD4 variants in New Zealand IBD patients and in New Zealand Caucasians

From: Nucleotide-binding oligomerization domain containing 1 (NOD1) haplotypes and single nucleotide polymorphisms modify susceptibility to inflammatory bowel diseases in a New Zealand caucasian population: a case-control study

SNP

Controls

CD

UC

CD+UC

 

n (%)

n (%)

OR

(95% CI)

n (%)

OR

(95% CI)

n (%)

OR

(95% CI)

NOD1 rs2075818

       

CC

105 (52.2)

255 (66.7)

1.29

(0.56–2.98)

226 (56.5)

0.61

(0.28–1.31)

481 (61.4)

0.84

(0.40–1.77)

CG

87 (43.3)

111 (29.0)

0.68

(0.29–1.59)

142 (35.5)

0.46

(0.21–1.01)

253 (32.3)

0.53

(0.25–1.13)

GG

9

(4.5)

17 (4.4)

1.00

32 (8.0)

1.00

49 (6.3)

1.00

Genotype p-value

 

0.002

0.08

0.01

HWE p-value

0.10

0.28

0.15

0.05

G

105 (26.1)

145 (18.9)

206 (25.8)

351 (22.4)

C

297 (73.9)

621 (81.1)

594 (74.3)

1215 (77.6)

OR (95% CI)

 

0.66 (0.49–0.89)

0.98 (0.74–1.30)

0.82 (0.63–1.06)

Allelic p-value

 

0.004

0.89

0.12

NOD1 rs2075822

       

CC

20 (10.0)

28

(7.3)

1.00

17

(4.2)

1.00

45

(5.7)

1.00

CT

60 (30.0)

122 (31.9)

1.45

(0.76–2.79)

135 (33.6)

2.65

(1.29–5.41)

257 (32.8)

1.90

(1.05–3.46)

TT

120 (60.0)

232 (60.7)

1.38

(0.75–2.55)

250 (62.2)

2.45

(1.23–4.85)

482 (61.5)

1.79

(1.02–3.14)

Genotype p-value

 

0.52

0.02

0.09

HWE p-value

0.007

0.04

0.82

0.17

C

100 (25.0)

178 (23.3)

169 (21.0)

347 (22.1)

T

300 (75.0)

586 (76.7)

635 (79.0)

1221 (77.9)

OR (95% CI)

 

0.91 (0.69–1.21)

0.80 (0.60–1.06)

0.85 (0.66–1.10)

Allelic p-value

 

0.52

0.12

0.22

NOD1 rs2907748

       

AA

21 (10.3)

31

(8.2)

1.00

20

(5.0)

1.00

51

(6.6)

1.00

AG

73 (36.7)

129 (34.3)

1.20

(0.64–2.23)

161 (40.3)

2.32

(1.18–4.53)

290 (37.4)

1.64

(0.93–2.89)

GG

105 (52.8)

216 (57.4)

1.39

(0.76–2.54)

219 (54.7)

2.19

(1.14–4.22)

435 (56.1)

1.71

(0.98–2.96)

Genotype p-value

 

0.48

0.04

0.16

HWE p-value

0.12

0.07

0.16

0.78

A

115 (28.9)

191 (25.4)

201 (25.1)

392 (25.3)

G

283 (71.1)

561 (74.6)

599 (74.9)

1160 (74.7)

OR (95% CI)

 

0.84 (0.64–1.10)

0.83 (0.63–1.08)

0.83 (0.65–1.06)

Allelic p-value

 

0.20

0.16

0.14